Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride and Hair TransplantationSidharth Sonthalia1*, Deepashree Daulatabad2 and Antonella Tosti3
- *Corresponding Author:
- Sidharth Sonthalia
Skinnocence: The Skin Clinic and Research centre
Sushant Lok-1, Gurgaon-122009, Haryana, India
E-mail: [email protected]
Received date: December 19, 2015; Accepted date: January 20, 2016; Published date: January 25, 2016
Citation: Sonthalia S, Daulatabad D, Tosti A (2016) Hair Restoration in Androgenetic Alopecia: Looking Beyond Minoxidil, Finasteride and Hair Transplantation. J Cosmo Trichol 2:105. doi:10.4172/2471-9323.1000105
Copyright: ©2015 Sonthalia S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Patterned hair loss (PHL) is one of the most commonly encountered problems for dermatologists. PHL at an early age is often cosmetically unacceptable, tends to be persistent and inflicts a profound negative impact on one’s quality of life. Androgenetic alopecia (AGA) affects both genders in a distinctive pattern of hair loss from the scalp (MPHL for male PHL and FPHL or female PHL). The etiopathogenesis of AGA is complex, so far the major factor emphasized to be involved has been the undesirable androgen metabolism at the hair follicle level. In this review article, we shall dwell upon the relatively newly understood pathophysiological factors behind the genesis of AGA apart from the hormonal factors like the Wnt/β-catenin pathway, follicular micro-inflammation, prostaglandin imbalance, loss of extracellular matrix and oxidative stress. Based on the sound understanding of these factors we will be elaborating upon therapies for treatment of AGA beyong minoxidil, finasteride and hair transplantation. Amongst the therapeutic options discussed include topical 5alpha reductase (AR) inhibitors like finasteride, oral 5AR inhibitor – dual receptor antagonist dutasteride, botanical 5AR inhibitors, oral anti-androgens and estrogens for FPHL like spiranolactone, drospirenone etc. Wnt/β-catenin activators like topical valproic acid, hair stem cell based therapies, prostaglandin based therapies, tetrapeptides, nutritional and anti-oxidants and many more.