Handcrafted Microwire Regenerative Peripheral Nerve Interfaces with Wireless Neural Recording and Stimulation CapabilitiesAli Ajam1, Ridwan Hossain1, Nishat Tasnim1, Luis Castanuela1, Raul Ramos1, Dongchul Kim2 and Yoonsu Choi1*
- *Corresponding Author:
- Yoonsu Choi
Department of Electrical Engineering
University of Texas Rio Grande Valley
Edinburg, Texas, 78539, USA
E-mail: [email protected]
Received date: December 10, 2015 Accepted date: January 06, 2016 Published date: January 13, 2016
Citation: Ajam A, Hossain R, Tasnim N, Castanuela L, Ramos R, et al. (2016) Handcrafted Microwire Regenerative Peripheral Nerve Interfaces with Wireless Neural Recording and Stimulation Capabilities. Sensor Netw Data Commun 5:133.doi:10.4172/2090-4886.1000133
Copyright: © 2016 Ajam A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A scalable microwire peripheral nerve interface was developed, which interacted with regenerated peripheral nerves in microchannel scaffolds. Neural interface technologies are envisioned to facilitate direct connections between the nervous system and external technologies such as limb prosthetics or data acquisition systems for further processing. Presented here is an animal study using a handcrafted microwire regenerative peripheral nerve interface, a novel neural interface device for communicating with peripheral nerves. The neural interface studies using animal models are crucial in the evaluation of efficacy and safety of implantable medical devices before their use in clinical studies. 16-electrode microwire microchannel scaffolds were developed for both peripheral nerve regeneration and peripheral nerve interfacing. The microchannels were used for nerve regeneration pathways as a scaffolding material and the embedded microwires were used as a recording electrode to capture neural signals from the regenerated peripheral nerves. Wireless stimulation and recording capabilities were also incorporated to the developed peripheral nerve interface which gave the freedom of the complex experimental setting of wired data acquisition systems and minimized the potential infection of the animals from the wire connections. A commercially available wireless recording system was efficiently adopted to the peripheral nerve interface. The 32-channel wireless recording system covered 16-electrode microwires in the peripheral nerve interface, two cuff electrodes, and two electromyography electrodes. The 2-channel wireless stimulation system was connected to a cuff electrode on the sciatic nerve branch and was used to make evoked signals which went through the regenerated peripheral nerves and were captured by the wireless recording system at a different location. The successful wireless communication was demonstrated in the result section and the future goals of a wireless neural interface for chronic implants and clinical trials were discussed together.