alexa Harmful Interactions of Non-Essential Heavy Metals with Cells of the Innate Immune System
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Harmful Interactions of Non-Essential Heavy Metals with Cells of the Innate Immune System

Theron AJ1,2*, Tintinger GR1, Anderson R1,2

1Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, South Africa

2Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa

*Corresponding Author:
Theron AJ
Department of Immunology
PO Box 2034
Pretoria-0001, South Africa
Tel: +27-12-319-2623
Fax: +27-12-323-0732
E-mail: [email protected]

Received Date: February 27, 2012; Accepted Date: April 13, 2012; Published Date: April 16, 2012

Citation: Theron AJ, Tintinger GR, Anderson R (2012) Harmful Interactions of Non- Essential Heavy Metals with Cells of the Innate Immune System. J Clinic Toxicol S3:005. doi: 10.4172/2161-0495.S3-005

Copyright: © 2012 Theron AJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In trace amounts, some heavy metals are essential for optimum health, while exposure to others, which are non-essential, presents the potential hazard of acute or chronic organ toxicity. Cadmium, mercury, lead, vanadium, platinum and palladium are commonly encountered, non-essential heavy metals which mediate their toxic activities by various mechanisms. All have the potential to interact with extracellular and intracellular protein sulfhydryls, rendering them not only potentially allergenic, but also predisposing to oxidative stress, while displacement of essential elements from their protein carriers may result in deficiency disorders. In addition, several of these metals, especially cadmium, palladium, platinum, and vanadium interact pro-oxidatively with the phagocytic cells of the innate immune system, potentiating the reactivity and toxicity of phagocyte-derived reactive oxygen species. This review is focused on the pro-oxidative/pro-inflammatory interactions of non-essential heavy metals with the cells of the innate immune system, a somewhat under-appreciated mechanism of metal induced toxicity.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords