Journal of Pharmacovigilance

Abstract

Chronic Hepatitis C (CHC) Treatment in Two Cystic Fibrosis (CF) Patients

Marianna Passiu, Ilaria Meneghelli and Baroukh Maurice Assael

Chronic Hepatitis C (CHC) is a contraindication for Lung Transplantation (LT). Infected patients may not be accepted in waiting lists. The standard treatment of viral hepatitis C infection (HCV) is pegylated interferon in association with ribavirin, which may lead to a sustained response but is not devoid of side effects. In Cystic Fibrosis (CF) patients this treatment could increase respiratory infections with subsequent pulmonary function deterioration. Here we present two CF adult patients who developed HCV infection. We decided to treat them in order to eradicate the virus and to allow future LT. Virological response was sustained and mild side effects were successfully managed, so we recommend treatment with interferon plus ribavirin for HCV infected CF patients.