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HE4 and CA72.4 are Useful Biomarkers in the Follow-up of Epithelial Ovarian Cancer | OMICS International | Abstract

Journal of Molecular Biomarkers & Diagnosis
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Research Article

HE4 and CA72.4 are Useful Biomarkers in the Follow-up of Epithelial Ovarian Cancer

Emanuela Anastasi1*, Teresa Granato2, Flavia Longo1, Valentina Viggiani1 and Luigi Frati1

1Department of Molecular Medicine, “Sapienza”, University, Viale Regina Elena 324, 00161 Roma, Italy

2CNR-IBPM, Consiglio Nazionale delle Ricerche, Viale Regina Elena 324, 00161 Roma, Italy

*Corresponding Author:
Emanuela Anastasi
Laboratory of Tumor Markers
Department of Molecular Medicine, University “Sapienza”
Viale Regina Elena 324, 00161 Rome, Italy
Tel: +39 064472347
Fax: +39 064478381
E-mail: [email protected]

Received date: December 12, 2011; Accepted date: December 30, 2011; Published date: January 06, 2012

Citation: Anastasi E, Granato T, Longo F, Viggiani V, Frati L (2012) HE4 and CA72.4 are Useful Biomarkers in the Follow-up of Epithelial Ovarian Cancer. J Mol Biomark Diagn 3:122. doi:10.4172/2155-9929.1000122

Copyright: © 2012 Anastasi E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The aim of this study was to investigate the role of serum biomarkers HE4 and CA72.4 at diagnosis and in the follow-up of patients with epithelial ovarian cancer (EOC).Seventy-eight patients with EOC were included and 40 of them were monitored during the follow-up. Serum levels of HE4 and CA72.4 were determined for all patients at diagnosis. Among these patients, the number of cases with an elevated level of each individual marker HE4 and CA72.4 was 85% and 72% respectively. A statistically significant difference was observed between the positivity of HE4 in comparison with Ca72.4 (p<0.02). In the follow-up period, we observed that tumor marker levels showed fluctuations during chemotherapy. As we combined the individual biomarkers, we observed increased values in 75% of the patients for HE4 with CA 72.4. In conclusion, our study has shown that the association of the biomarkers HE4 and CA72.4 provides a valuable contribution to the follow-up of EOC.


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