Heat Shock Proteins: Heating up skin cancer biologyPrabir Kumar Chakraborty1,#,* and Soumyajit Banerjee Mustafi2,#
- *Corresponding Author:
- Chakraborty PK
Department of Pathology and Department of Obstetrics and Gynecology
Oklahoma City, Oklahoma, USA
Tel: 405 271 7184
E-mail: [email protected]
Received date: November 03, 2015; Accepted date: December 19, 2015; Published: January 05, 2016
Citation: ChakrabortyPK and Mustafi SB (2016) Heat Shock Proteins: Heatingup skin cancer biology. J Dermatitis 1:102. doi: 10.4172/jod.1000102
Copyright: © 2016 Chakraborty and Mustafi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Heat shock proteins (HSPs) are molecular chaperones with significant role in various physiological processes and pathological conditions including cancer. Certain cytotoxic insults or heat stress causes activation of the HSPs, which prevent cells from undergoing apoptosis and maintenance of cellular function. However, activation of HSPs also has detrimental effects particularly if the cells evading apoptosis possess oncogenic mutations. Over that last few decades there has been a steady rise in incidence of skin cancer globally and recent scientific and epidemiological evidence hypothesize that heat stress could also be a risk factor of skin carcinogenesis. More recently, HSP based vaccines have shown promise in treatment of early stage melanoma. Therefore, the aim of this article is to summarize the main concepts related to the expression and function of HSPs, from analysis of HSPs role in skin cancer and present final considerations related to HSP targeted therapy in this area.