alexa Helicobacter pylori Infection is Associated with an Increased Risk of Developing Squamous Cell Carcinoma of the Oesophagus. A Cross Sectional Case Control Prospective Study
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

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Research Article

Helicobacter pylori Infection is Associated with an Increased Risk of Developing Squamous Cell Carcinoma of the Oesophagus. A Cross Sectional Case Control Prospective Study

Mpho Kgomo*, Elnagar AA, Mokoena T, Mashoshoe S and Nagel GJ

University of Pretoria School of Health Systems and Public Health, Pretoria, Gauteng, South Africa

Corresponding Author:
Kgomo M
University of Pretoria School of Health Systems and Public Health
Pretoria, Gauteng, South Africa
Tel: +27 (0)12 356 3064
E-mail: [email protected]

Received Date: July 31, 2016; Accepted Date: August 12, 2016; Published Date: August 19, 2016

Citation: Kgomo M, Elnagar AA, Mokoena T, Mashoshoe S, Nagel GJ (2016) Helicobacter pylori Infection is Associated with an Increased Risk of Developing Squamous Cell Carcinoma of the Oesophagus. A Cross Sectional Case Control Prospective Study. J Bioanal Biomed 8:063-065. doi:10.4172/1948-593X.1000154

Copyright: © 2016 Kgomo M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Helicobacter pylori is an important causative factor in gastric carcinogenesis, its role in extra-gastric gastrointestinal malignancies such as oesophageal cancer, is controversial. H. pylori is thought to be associated with an increased risk of squamous cell carcinoma of the oesophagus. We conducted a case control study to determine the prevalence of H. pylori infection in patients with squamous cell carcinoma of the oesophagus and control group with no cancer.

Method: We collected biopsies from the antrum and corpus of 59 patients with confirmed squamous cell carcinoma of the oesophagus, two from each area and 215 control groups with no cancer. These were then examined by an experienced histo-pathologist using Giemsa staining for the presence of H. pylori. CLO was added to those with bleeding ulcers.

Results: H. pylori was found in 30 (51%) of the patients with squamous cell carcinoma of the oesophagus and 46 (21%) of the control group. The prevalence was found to be more than double of the control group in patients with squamous cell carcinoma of the oesophagus. A relative risk of 2.4 p<0.001 CI OF 95%.

Conclusion: H. pylori infection is associated with an increased risk of developing squamous cell carcinoma of the oesophagus with a relative risk of 2.4. This is in keeping with several studies done previously.

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