alexa Helminth Infections Mediated DNA Damage: Mechanisms and Consequences | OMICS International
ISSN: 2168-9431

Single Cell Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Helminth Infections Mediated DNA Damage: Mechanisms and Consequences

Rashmi Tripathi1, Neeshma Jaiswal2, Bechan Sharma3 and Sandeep K. Malhotra2*
1Department of Zoology, Banasthali University, Banasthali, Rajasthan-304022, India
2Parasitology Laboratory, Department of Zoology, University of Allahabad, Allahabad-211 002, U.P., India
3Department of Biochemistry, University of Allahabad, Allahabad-211 002, U.P., India
Corresponding Author : Sandeep K. Malhotra
Parasitology Laboratory
Department of Zoology
University of Allahabad, Allahabad-211 002
U.P., India
Tel: 0532 246 1083
E-mail: [email protected]
Received June 23, 2015; Accepted July 23, 2015; Published July 25, 2015
Citation:Tripathi R, Jaiswal N, Sharma B, Malhotra SK (2015) Helminth Infections Mediated DNA Damage: Mechanisms and Consequences. Single Cell Biol 4:117. doi:10.4172/2168-9431.1000117
Copyright: ©2015 Tripathi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google

Abstract

According to an estimate, the chronic infections caused by certain pathogens such as viruses, bacteria, fungi and parasites contribute to about 18% of the global burden of cancer; helminth infections attributing to only small part of it. Carcinogenesis associated with the helminthes infections induced development of cancer is a complicated event involving several different mechanisms varying from one species of parasite to another. Parasite infections evoke immune responses in the host which finally result into inflammatory reactions. The chronic inflammatory processes produce reactive oxygen species (ROS) and reactive nitrogen species (RNS). These free radicals may cause DNA damage resulting into genetic instabilities and occurrence of malignancy. The parasites or their eggs or their excretory-secretary products exhibit potential to induce proliferation of some cells in the affected tissues which harbor DNA damage. The existing reports indicate that helminth infections may trigger cancer in the organs of their infection for example Clonorchis sinensis and Opisthorchis viverrini may induce cholangiocarcinoma (cancer of gall bladder and hepatocarcinoma) and Schistosoma haematobium and its other species are known to cause urinary bladder cancer. In many cases of helminth infections mediated carcinogenesis, the DNA damage by free radicals or inflammatory responses at damaged host tissues is demonstrated. Therefore the knowledge about the mechanisms of helminthes mediated DNA damage may be of great importance in management of parasite infections and reduction of incidences of parasites induced cancer thereby improving the quality of human lives. This article presents an updated account of helminthes infection mediated genotoxicity, DNA damage mechanisms and consequences.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version