alexa Hemagglutinating Virus of Japan Envelope Vectors as High-Performance Vehicles for Delivery of Small RNAs
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
Open Access

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Review Article

Hemagglutinating Virus of Japan Envelope Vectors as High-Performance Vehicles for Delivery of Small RNAs

Fuminori Kato1*, Takaharu Yagi1, Takayuki Fujieda1, Yoshitaka Kondo1, Tomona Yamaguchi1, Keizo Miyata2 and Yasufumi Kaneda3

1Central Research Institute, Ishihara Sangyo Kaisha, Ltd, Japan

2Life Science Technology Development Division, Ishihara Sangyo Kaisha, Ltd, Japan

3Division of Gene Therapy Science, Osaka University, Graduate School of Medicine, Japan

*Corresponding Author:
Fuminori Kato
Life Science Research Laboratory
Central Research Institute, Ishihara Sangyo Kaisha
Ltd., Shiga 525-0025, Japan
Tel: +08 77 562 8881
Fax: +08 77 562 9783
E-mail: [email protected]

Received date: July 26, 2013; Accepted date:September 10, 2013; Published date: September 19, 2013

Citation: Kato F, Yagi T, Fujieda T, Kondo Y, Yamaguchi T, et al. (2013) Hemagglutinating Virus of Japan Envelope Vectors as High-Performance Vehicles for Delivery of Small RNAs. J Genet Syndr Gene Ther 4:178.doi:10.4172/2157-7412.1000178

Copyright: © 2013 Kato F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Hemagglutinating virus of Japan envelope (HVJ-E) vectors are particulate forms of the Sendai virus, and are characterized by maintained cell membrane fusion activities and completely inactivated genomes. HVJ-E vectors can be safely used as a non-viral transfection tools for laboratory research without the need for special protocols or equipment. HVJ-E particles are loaded with molecules such as DNA, proteins, antisense oligonucleotides, or small RNAs, to form HVJ-E vectors that carry these molecules into target cells by virtue of their membrane fusion activity. Interference by small RNAs such as small interfering RNA (siRNA) and microRNA (miRNA) is now established as an important biological strategy for gene silencing, and is becoming an essential method for analyzing biological processes. Various delivery reagents are currently available globally; however, delivery to non-adherent immune cells, particularly primary immune cells, remains extremely difficult. The simple and effective delivery capabilities of HVJ-E vectors overcome the above obstacle. Here we describe examples and demonstrate the utility and potential applications of HVJ-E vectors as high-performance vehicles for delivery of small RNAs.

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