alexa Hematic Cortisol and Craniofacial Morphology in Children with OSAS | OMICS International | Abstract
ISSN: 2167-0277

Journal of Sleep Disorders & Therapy
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Research Article

Hematic Cortisol and Craniofacial Morphology in Children with OSAS

Alberto Caprioglio1*, Alessandro Ollà2, Franca Marino3, Gian Marco Abbate2, Federico Migliori2, Carlo Mangano4, Marco Cosentino5 and Luana Nosetti6
1Associated Professor and Head, Department of Orthodontics, School of Dentistry, University of Insubria, Italy
2DDS, Department of Orthodontics, School of Dentistry, University of Insubria, Italy
3Assistant Professor, Centre of Research in Medical Pharmacology, School of Medicine, University of Insubria, Italy
4Assistant Professor, Department of Oral Surgery, School of Medicine, University of Insubria, Italy
5Associated Professor and Head, Centre of Research in Medical Pharmacology, School of Medicine, University of Insubria, Italy
6Assistant Professor, Department of Pediatrics, School of Medicine, University of Insubria, Italy
Corresponding Author : Alberto Caprioglio
Department of Orthodontics, University of Insubria
Via Piatti, 10 – Varese, Italy
Tel: +39 3474302744
E-mail:[email protected]
Received May 25, 2013; Accepted August 26, 2013; Published August 30, 2013
Citation: Caprioglio A, Ollà A, Marino F, Abbate GM, Migliori F, et al. (2013) Hematic Cortisol and Craniofacial Morphology in Children with OSAS. J Sleep Disord Ther 2:136 doi:10.4172/2167-0277.1000136
Copyright: © 2013 Caprioglio A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Study objectives: This study wanted to evaluate the correlations between haematic cortisol levels and the craniofacial morphology in children with Obstructive Sleep Apnoea Syndrome (OSAS) in comparison with healthy children.

Design/setting/patients. This is a case-control study. Children referring to the Paediatric Department, University of Insubria, Varese, in the period between 1st and 31st October 2011 for a history of disturbed sleep were evaluated and 28 children, compliant to our criteria, were enrolled in the study.

Interventions: All patients underwent a full-night polysomnographic evaluation. Haematic cortisol levels were measured using a radioimmunoassay technique. An orthodontic evaluation and a cranial lateral cephalometric analysis were performed.

Measurements and results: Haematic cortisol concentration at 2.00 am was found higher in OSAS patients than in controls (p<0.05). An increase in craniomandibular (p<0.05) and intermaxillar (p<0.01) angles indicated a high angle tendency in OSAS with a posterior rotation of the mandible. A retro-position of the mandible (p<0.05), an increased overjet (p<0.01) and a reduction of overbite (p<0.01) were also found.

Conclusions: The altered hypothalamic-pituitary-adrenal activity and the craniofacial modification found are not enough to state if these conditions are causes rather than consequences of OSAS. Moreover cortisol and sleep fragmentation can cause a reduction of growth hormone secretion so it is possible that the alteration of facial morphology may also have a metabolic cause.

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