alexa Hematological Markers of In Vivo Toxicity
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Review Article

Hematological Markers of In Vivo Toxicity

Arika WM*, Nyamai DW, Musila MN, Ngugi MP and Njagi ENM
Department of Biochemistry and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya
*Corresponding Author : Arika WM
Department of Biochemistry and Biotechnology
Kenyatta University, P.O. Box 43844-00100
Nairobi, Kenya
Tel: 254722863595
Email: [email protected]
Rec date: February 29, 2016; Acc date: March 22, 2016; Pub date: 29 March, 2016
Citation: Arika WM, Nyamai DW, Musila MN, Ngugi MP, Njagi ENM (2016) Hematological Markers of In Vivo Toxicity. J Hematol Thrombo Dis 4:236. doi:10.4172/2329-8790.1000236
Copyright: © 2016 Arika WM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In modern medical practice, toxicity studies are essential in assessment of safety of extracts or drugs used in clinical medicine. The interaction of the toxin or its metabolite with cellular constituents may bring about significant changes in hematological parameters. These alterations may be rapid or slow and often cause a change in structure and function of the affected tissues. In clinical laboratory setting these blood indices are assayed for the purpose of diagnosis, treatment or prevention of disease, and for greater understanding of the disease process. Therefore, assessment of hematological indices can be diagnostic of adverse effects of foreign compounds on the blood constituents since such hematological alterations have higher predictive value for human toxicity when the data are interpreted from animal studies.


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