Hematological Responses and Percentage Parastaemia in Malaria-Infected Mice Treated with Ethanol Extract of Zapoteca portoricensis Roots
Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
- *Corresponding Author:
- Joshua Parker E,
Department of Biochemistry
Faculty of Biological Sciences
University of Nigeria
Nsukka, Enugu State, Nigeria
Tel: +2348065914471; +2347065504459; +2348037804687
E-mail: [email protected]
Received Date: February 08, 2016; Accepted Date: February 23, 2016; Published Date: February 26, 2016
Citation: Parker EJ, Mary CU, Nwodo Okwesili FC, Ikechukwu UR (2016) Hematological Responses and Percentage Parastaemia in Malaria-Infected Mice Treated with Ethanol Extract of Zapoteca portoricensis Roots. Biochem Anal Biochem 5:252. doi:10.4172/2161-1009.1000252
Copyright: © 2016 Parker J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The increasing use of Zapoteca portoricensis roots in the treatment of malaria has necessitated the need to assay for the haematological responses and parasitaemia levels in malaria-infected mice treated with ethanol extract of Zapoteca portoricensis roots. This was done by determining the percentage parasitaemia and some haematological parameters such as packed cell volume (PCV), haemoglobin concentration (Hb), total white blood cell count (TWBC) and red blood cell count (RBC). The Zapoteca portoricensis roots were randomly collected from Umabor Ehalumona, Nsukka, Enugu State, Nigeria. Treatment of infected mice with the ethanol extract of Zapoteca portoricensis roots caused mean percentage parasitaemia to reduce significantly (p < 0.05) in groups 4, 5 and 6 administered 100, 200 and 300 mg/kg b.w. of the extract respectively when compared to the group 2 mice (malaria untreated). Haematological parameters such as PCV, Hb concentration and RBC count significantly (p < 0.05) increased in groups 4, 5 and 6 administered 100, 200 and 300 mg/kg b.w. of the extract respectively when compared to group 2 (malaria untreated) but TWBC count did not change significantly (p > 0.05) in the controls, group 1 (normal control), groups 2 (malaria untreated) and 3 administered 28 mg/kg b.w. of artemether and lumefantrine and test groups 4 and 6 administered 100 and 300 mg/kg b.w. of the extract respectively. The investigation validated the use of the root extract of Zapoteca portoricensis in the treatment of malaria in traditional medicine.