Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
- *Corresponding Author:
- Jichun Chen
Hematology Branch, National Heart, Lung, and Blood Institute
National Institutes of Health, Bethesda, MD USA
E-mail: [email protected]
Received date: January 10, 2017; Accepted date: February 03, 2017; Published date: February 06, 2017
Citation: Lin Z, Kajigaya, Feng X, Chen J, Young NS (2017) Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice. J Aging Sci 5:169. doi:10.4172/2329-8847.1000169
Copyright: © 2017 Lin Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2-9 months), middle (22-23 months) and old (33-46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44+ cells in blood, spleen and bone marrow in old PL mice than in middle and young counterparts. We conclude that elevated blood monocyte counts and up-regulated hematopoietic cell CD44 expression are two useful aging biomarkers for PL mice.