alexa Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use

Márta Szekeres1*, Erzsébet Illés1, Christina Janko2, Katalin Farkas3, Ildikó Y Tóth1, Dániel Nesztor1, István Zupkó4, Imre Földesi3, Christoph Alexiou2 and Etelka Tombácz1*

1Department of Physical Chemistry and Materials Science, University of Szeged, Aradi vt 1, 6720 Szeged, Hungary

2Department of Otorhinolaryngology, Head and Neck Surgery, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen, Glückstraße 10a, 91054 Erlangen, Germany

3Institute of Laboratory Medicine, Faculty of Medicine, University of Szeged, Semmelweis u. 6, 6720 Szeged, Hungary

4Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 1, 6720 Szeged, Hungary

*Corresponding Author:
Szekeres M
Department of Physical Chemistry and Materials Science
University of Szeged, Aradi vt 1
6720 Szeged, Hungary
Tel: 36-62544212
E-mail: [email protected]

Tombácz E
Department of Physical Chemistry and Materials Science
University of Szeged, Aradi vt 1
6720 Szeged, Hungary
Tel: 36-62544212;
E-mail: [email protected]

Received Date: October 13, 2014; Accepted Date: December 10, 2014; Published Date: January 01, 2015

Citation: Szekeres M, Illés E, Janko C, Farkas K, Tóth IY, et al. (2015) Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use. J Nanomed Nanotechnol 5:252. doi:10.4172/2157-7439.1000252

Copyright: © 2015 Szekeres M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Polyacid covered core-shell iron oxide nanoparticles were designed for potential use in biomedicine with special attention to theranostics - magnetic resonance imaging (MRI), magnetic hyperthermia and magnetic drug targeting. The magnetite nanoparticles coated with a gallic acid shell polymerized in situ on the nanoparticle surface ([email protected]) were tested for hemocompatibility in blood, sedimentation rate, blood smear and blood cell viability experiments and for antioxidant capacity in Jurkat cells in the presence of H2O2 as reactive oxygen species. No signs of interaction of the nanoparticles with whole blood cells were found. In addition, the [email protected] reduced significantly the oxidative stress mediated by H2O2 supporting earlier findings of MTT tests, namely, the improvement of cell viability in their presence. The in vitro tests revealed that [email protected] are not only biocompatible but also bioactive. Preliminary experiments revealed that the nanoparticles are especially efficient MRI and magnetic hyperthermia agents. The r2 relaxivity was found to be one of the highest among published values (387 mM-1s-1) and they possess a relatively significant specific absorption rate (SAR) value of 11 W/g magnetite.

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