alexa Hemodynamic Consequences of Hypertrophic Cardiomyopathy with Midventricular Obstruction: Apical Aneurysm and Thrombus Formation
ISSN: 2329-9126

Journal of General Practice
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Case Report

Hemodynamic Consequences of Hypertrophic Cardiomyopathy with Midventricular Obstruction: Apical Aneurysm and Thrombus Formation

Shahryar G Saba*, Andrew W Ertel, Michael Siegenthaler, Edward Bodurian, Peter Kellman, Marcus Y Chen, Andrew E Arai
and W Patricia Bandettini
Laboratory of Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, USA
Corresponding Author : Shahryar G Saba
National Heart, Lung, and Blood Institute
National Institutes of Health, 10 Center Drive
MSC 1061 Building 10, Room B1D416, Bethesda, MD 20892, USA
Tel: 3015943475
Received March 30, 2014; Accepted May 21, 2014; Published May 26, 2014
Citation: Saba SG, Ertel AW, Siegenthaler M, Bodurian E, and Kellman P et al. (2014) Hemodynamic Consequences of Hypertrophic Cardiomyopathy with Midventricular Obstruction: Apical Aneurysm and Thrombus Formation. J Gen Pract 2:161. doi: 10.4172/2329-9126.1000161
Copyright: © 2014 Saba SG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Background: Hypertrophic cardiomyopathy (HCM) with midventricular hypertrophy is an uncommon phenotypic variant of the disease. Midventricular hypertrophy predisposes to intracavitary obstruction and downstream hemodynamic sequelae.
Case report: We present a case of HCM with midventricular hypertrophy and obstruction diagnosed after a CT scan of the abdomen incidentally revealed a filling defect in the left ventricular apex. Transthoracic echocardiography demonstrated mid left ventricular hypertrophy and obstruction, as well as an aneurysmal apex containing a large thrombus. Cardiovascular MRI showed a spade-shaped left ventricle with midcavitary obliteration, an infarcted apex and regions of myocardial fibrosis. Due to the risk of embolization and a relative contraindication to anticoagulation, the patient underwent surgery including thrombectomy, septal myectomy and aneurysmal ligation.
Conclusions: Hypertrophic cardiomyopathy with midventricular hypertrophy leads to cavity obstruction, increased apical wall tension, ischemia and ultimately fibrosis. Over time, patchy apical fibrosis can develop into a confluent scar resembling a transmural myocardial infarction in the left anterior descending coronary artery distribution. Aneurysmal remodeling of the left ventricular apex potentiates thrombus formation and risk of cardioembolism. For these reasons, hypertrophic cardiomyopathy with midventricular obstruction portends a particularly poor prognosis and should be recognized early in the disease process.


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