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Hepatic Epithelioid Hemangioendothelioma with Cecal Metastasis in a Natural Course: A Case Report | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Case Report

Hepatic Epithelioid Hemangioendothelioma with Cecal Metastasis in a Natural Course: A Case Report

Ying-Ren Chen1, Chien-Hsien Lai2, Liang-Yi Hung2, Kung-Chao Chang1*

1Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

2Institute of Bioinformatics and Bio signal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan

*Corresponding Author:
Kung-Chao Chang
Department of Pathology, College of Medicine
National Cheng Kung University and Hospital
138 Sheng-Li Road, Tainan, 704, Taiwan
Tel: 886-6-235-3535 ext. 2636
Fax: 886-6-276-6195
E-mail: [email protected]

Received Date: Jan 29, 2016; Accepted Date: Mar 08, 2016; Published Date: Mar 18, 2016

Citation: Chen Y, Lai C, Hung L,Chang K (2016) Hepatic Epithelioid Hemangioendothelioma with Cecal Metastasis in a Natural Course: A Case Report. J Cytol Histol 7:398. doi:10.4172/2157-7099.1000398

Copyright: © 2016 Chen Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor of low malignant potential that occurs mostly in soft tissue. So far, only two cases of EHE involving the intestine have been recorded. Here, we describe a rare case of cecal EHE due to a subsequent metastasis from the primary liver tumor three years after initial diagnosis. A 74- year-old man had sudden onset of epigastralgia for 24 hours. The abdominal CT revealed an ileocecal mass with a small bowel obstruction, and extensive tumor involvement in the liver was noted. He received an emergent right hemicolectomy for relief of the ileus. Unfortunately, he expired four days later due to septic shock. The pathologic diagnosis of EHE prompted a molecular study for a WWTR1-CAMTA1 fusion. The Sanger sequencing results showed the fusion involved exon 4 of WWTR1 with exon 8 of CAMTA1. There is no standard treatment for hepatic EHE because of its rarity and variable clinical outcome. The decision on a treatment strategy should be individualized for each patient. Since the patient received supportive care only for the liver tumor, this case demonstrated a natural course of hepatic EHE with a survival of more than 3.3 years.