alexa Hepatic Steatosis Markers in Diabetic Rats Trained at t
ISSN: 2167-0889

Journal of Liver
Open Access

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Research Article

Hepatic Steatosis Markers in Diabetic Rats Trained at the Aerobic/ Anaerobic Transition

Leandro Pereira de Moura1*, Ricardo José Gomes2, José Alexandre Curiacos de Almeida Leme1, Michel Barbosa de Araújo1 and Maria Alice Rostom de Mello1
1São Paulo State University, Physical Education Departament- Rio Claro/SP, Brazil
2Universidade Federal de São Paulo, Departamento de Educação Física- Santos/SP, Brazil
Corresponding Author : Leandro Pereira de Moura
São Paulo State University
Physical Education Department
Rio Claro, SP, Brazil
Tel: +55(19)8197-9999
E-mail: [email protected]
Received October 30, 2013; Accepted November 29, 2013; Published December 07, 2013
Citation: de Moura LP, Gomes RJ, de Almeida Leme JAC, de Araújo MB, de Mello MAR (2013) Hepatic Steatosis Markers in Diabetic Rats Trained at the Aerobic/ Anaerobic Transition. J Liver 2:137. doi:10.4172/2167-0889.1000137
Copyright: © 2013 de Moura LP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aims: To analyze the effects of exercise performed at the aerobic/anaerobic transition (Lan) on Non-Alcoholic Hepatic Steatosis (NAHS) markers in type 1 diabetic rats.

Methods: Adult Wistar rats were separated into four groups: Sedentary Control (SC), Trained Control (TC), Sedentary Diabetic (SD) and Trained Diabetic (TD). The trained groups swam supporting workloads equivalent to the Lan for one hour/day, five days/week, for eight weeks. Body weight, serum albumin concentrations, glucose concentrations, Free Fatty Acid (FFA) concentrations, NAHS markers (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) and total lipid concentrations in the liver were analyzed.

Results: The diabetic groups showed higher serum glucose concentrations and more weight loss compared to the controls, although the TD group was less affected than the SD group. Training resulted in a decrease in serum glucose levels in the diabetic rats. The NAHS markers, total lipid concentrations in the liver and serum albumin concentrations did not differ between the groups. However, the diabetic animals had higher serum FFA levels than the controls.

Conclusion: Physical training at Lan attenuates weight loss and improves serum glucose homeostasis in diabetic animals. In addition, serum ALT and AST enzymes proved to be adequate markers of lipid levels in the livers in this animal model.


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