Hepatitis B Reactivation in Patients with Hematological Malignancies and Stem Cell Transplantation
Nishitha M Reddy* and Bipin N Savani
Section of Hematology and Stem Cell Transplantation, Division of Hematology/ ncology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA
- *Corresponding Author:
- Nishitha Reddy
Division of Hematology and Oncology
Department of Medicine
Vanderbilt University Medical center
1301 Medical Center Drive; 3927 TVC
TN-37232, Nashville, USA
E-mail: [email protected]
Received Date: July 27, 2013; Accepted Date: December 26, 2013; Published Date: December 30, 2013
Citation: Reddy NM, Savani BN (2013) Hepatitis B Reactivation in Patients with Hematological Malignancies and Stem Cell Transplantation. J Blood Lymph 4:114. doi: 10.4172/2165-7831.1000114
Copyright: © 2013 Reddy NM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hepatitis B infection is the leading cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma and is thought to be responsible for million deaths per year globally. Management of patients with resolved or active hepatitis B and cancer is a challenge and these patients are at higher risk of hepatitis B related complications due to immunosuppression and loss of prior immunity. The treating hematologist needs to understand the biology of this common virus, its potential for long-term harm, the necessary laboratory monitoring for their identification and characterization, and the pharmacological interventions for their control. This review offers a general approach to prevention and treatment of hepatitis B reactivation in patients with hematological malignancies and transplant recipients. Practitioners are also encouraged to seek advice and consultation from experts in the design of specific protocols for screening, monitoring and prevention.