alexa Hepatoprotective Activity of Boerhavia Diffusa Linn. (N

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Hepatoprotective Activity of Boerhavia Diffusa Linn. (Nyctaginaceae) against Ibuprofen Induced Hepatotoxicity in Wistar Albino Rats

To read the full article Peer-reviewed Article PDF image


The present study was designed to evaluate the hepatoprotective activity of different parts of Boerhavia diffusa Linn. (Nyctaginaceae) such as root and aerial parts against ibuprofen (IB) induced hepatotoxicity in Wistar albino rats. Boerhavia diffusa L. is one of the well known folklore medicinal plants. The administration of ibuprofen (500mg/kg. b. wt.) produced significant changes in the normal hepatic cells, resulting in the formation of gastric lesions, centrilobular necrosis, vacuolization, and hepatomegaly. The adverse effect of ibuprofen was reflected in the levels of biochemical parameters of liver marker enzymes such as ALT, AST, ALP, and bilirubin. The activities of natural antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and Glutathione-S-transferase (GST) were decreased significantly. The methanol extract (85%) of the root and aerial part of Boerhavia diffusa L. (500 mg/kg. b. wt.) produced remarkable changes in affected hepatic cell architecture and restored nearly normal structure and functions of hepatic cells. Similarly the different parts of the Boerhavia diffusa L. (500 mg/kg. b. wt.) restored the altered biochemical parameters of liver marker enzymes close to normal control levels. The observed results show the root of Boerhavia diffusa L. possesses more hepatoprotective efficacy than the aerial part of the same plant. The results suggest that the hydro alcoholic (15:85%) extract of Boerhavia diffusa L. possesses significant potential effect as a hepatoprotective agent.


Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthca[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version