Hepatoprotective Activity of Boerhavia Diffusa Linn. (Nyctaginaceae) against Ibuprofen Induced Hepatotoxicity in Wistar Albino Rats
The present study was designed to evaluate the hepatoprotective activity of different parts of Boerhavia diffusa Linn. (Nyctaginaceae) such as root and aerial parts against ibuprofen (IB) induced hepatotoxicity in Wistar albino rats. Boerhavia diffusa L. is one of the well known folklore medicinal plants. The administration of ibuprofen (500mg/kg. b. wt.) produced significant changes in the normal hepatic cells, resulting in the formation of gastric lesions, centrilobular necrosis, vacuolization, and hepatomegaly. The adverse effect of ibuprofen was reflected in the levels of biochemical parameters of liver marker enzymes such as ALT, AST, ALP, and bilirubin. The activities of natural antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and Glutathione-S-transferase (GST) were decreased significantly. The methanol extract (85%) of the root and aerial part of Boerhavia diffusa L. (500 mg/kg. b. wt.) produced remarkable changes in affected hepatic cell architecture and restored nearly normal structure and functions of hepatic cells. Similarly the different parts of the Boerhavia diffusa L. (500 mg/kg. b. wt.) restored the altered biochemical parameters of liver marker enzymes close to normal control levels. The observed results show the root of Boerhavia diffusa L. possesses more hepatoprotective efficacy than the aerial part of the same plant. The results suggest that the hydro alcoholic (15:85%) extract of Boerhavia diffusa L. possesses significant potential effect as a hepatoprotective agent.