alexa Hepatotoxicity after Sevoflurane Exposure in a Patient with Chronic Hepatitis C | OMICS International | Abstract
ISSN: 2165-8048

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Case Report

Hepatotoxicity after Sevoflurane Exposure in a Patient with Chronic Hepatitis C

Nickul Shah1*, Nina Ballone2, Raul Zamora3, Peter Devito4 and Samuel Wilson5
1American University of Antigua College of Medicine, USA
2Northeast Ohio Medical University, USA
3Northside Medical Center Department of Surgery, USA
4Northside Medical Center Department of Surgery, USA
5Northside Medical Center Department of Anesthesia, USA
Corresponding Author : Nickul Shah
American University of Antigua College of Medicine
Interfaith Medical Center, 1545 Atlantic Avenue
Brooklyn, NY 11213, USA
Tel: 413-244-3937
E-mail: [email protected]
Received: November 16, 2015 Accepted: November 25, 2015 Published: December 02, 2015
Citation: Shah N, Ballone N, Zamora R, Devito P, Wilson S (2015) Hepatotoxicity after Sevoflurane Exposure in a Patient with Chronic Hepatitis C. InternMed 5:209. doi:10.4172/2165-8048.1000209
Copyright: © 2015 Shah N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Sevoflurane is considered a safe inhaled anesthetic of choice in patients with liver disease. Compared to other halogenated inhaled anesthetics, Sevoflurane is reported to lessen the severity of decreased hepatic blood flow and undergoes a different mechanism of hepatic metabolism. In patients with preexisting liver disease, there is potential for low-flow Sevoflurane to induce acute liver damage through other mechanisms. Limited data exists to guide clinical decision-making when quantifying the severity of cirrhosis in patients with hepatitis C and its relationship to anesthesia choice. Previous studies have found that exposure to general anesthesia during abdominal surgery may increase the risk of hepatorenal failure. This study has raised a concern that anesthetics may interfere with various hepatic functions secondary to viral infection. The generation of abnormal liver enzymes and hypercoagulation has provided further exploration for such toxicity.

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