alexa HER2/Neu Protein Over-Expression in Patients with Gastric and Gastro- Esophageal Junction Carcinoma Seen at Kenyatta National Hospital, Kenya | OMICS International | Abstract
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

HER2/Neu Protein Over-Expression in Patients with Gastric and Gastro- Esophageal Junction Carcinoma Seen at Kenyatta National Hospital, Kenya

Ali Hussein A1, Rogena Emily2*, Omulo TM1 and Ndaguatha PLW1

1Department of Surgery, School of Medicine, College of Health Sciences, University of Nairobi, Kenya

2Department of Human Pathology, School of Medicine, College of Health Sciences, University of Nairobi, Kenya

*Corresponding Author:
Dr. Rogena Emily
Senior lecturer, Department of Human Pathology
School of Medicine, College of Health Sciences
University of Nairobi, Hospital Road
PO BOX 55050, Nairobi, Kenya 00200, Kenya
Tel: +254 721 674 647
E-mail: [email protected]

Received date: June 28, 2014; Accepted date: August 28, 2014; Published date: September 06, 2014

Citation: Hussein AA, Emily R, Omulo TM, Ndaguatha PLW (2014) HER2/Neu Protein Over-Expression in Patients with Gastric and Gastro-Esophageal Junction Carcinoma Seen at Kenyatta National Hospital, Kenya. J Carcinog Mutagen 5:186. doi: 10.4172/2157-2518.1000186

Copyright: © 2014 Hussein AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Gastric cancer in Kenya is ranked third in both males and females. Most patients present clinically with advanced unsusceptible disease have poor prognosis despite administration of standard chemotherapy. Human epidermal growth factor receptor–2 (HER-2) over expression in gastric cancer is related to poor outcome. Advances in molecular therapy, have identified HER-2 to be an important component in the treatment of advanced gastric cancer. The prevalence of HER-2 in Kenya is unknown.

Objective: To determine the prevalence of HER-2 overexpression in patients with gastric and gastro-oesophageal junction carcinoma at Kenyatta National Hospital.

Methodology: Descriptive Cross sectional study on patients with histological diagnosis from endoscopic/resection specimens of gastric or GEJ cancer at KNH. A sample of 66 patients was selected by progressive sampling. Approval was obtained from the KNH/UON ethics and research committee. Data was collected using a pretested questionnaire. All tissue blocks were tested for HER-2 receptor protein using IHC. Data entry and analysis was done via SPSS version 21.0.

Results: Study sample of 66 patients were included in the study with a mean age of 60.7 years and males consisting of 66.7%. 42 specimens were obtained from OGD and 24 from surgically resected specimens. Approximately 91% of the tumours were located in the gastric region. Gastric adenocarcinoma accounted for 89.4% (N=59) mainly intestinal (78.8%, N=52) and diffuse (9.1%, N=6) while 1.5% (N=1) was adeno-squamous. HER-2 over-expression was diagnosed in 42.4% (N=28) of patients. HER-2 over-expression was not significantly associated with age (P=0.844) and gender (P=0.682). The anatomical site was not significantly associated with HER-2 over-expression (P=1). HER-2 over-expression was found mostly in adenocarcinoma (96.4%) compared to 3.6% in adeno-squamous, with intestinal type showing highest rate of over-expression (87.5%) compared to diffuse (12.5%).

Conclusion: HER-2 over-expression was found to be higher in our study (42.4%) compared to most of the studies. HER-2 over-expression is observed predominantly in intestinal type of gastric and GEJ adenocarcinomas.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7