alexa Hesperidin, A Citrus Bioflavonoid Reduces the Oxidative Stress in the Skin of Mouse Exposed to Partial Body γ-Radiation
ISSN: 2329-8936

Transcriptomics: Open Access
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Research Article

Hesperidin, A Citrus Bioflavonoid Reduces the Oxidative Stress in the Skin of Mouse Exposed to Partial Body γ-Radiation

Ganesh Chandra Jagetia* and Mallikarjuna Rao KVN
Department of Zoology, Mizoram University, Tanhril, Aizawl-796 004, Mizoram, India
Corresponding Author : Ganesh Chandra Jagetia
Department of Zoology, Mizoram University
Tanhril, Aizawl-796 004, Mizoram, India
Tel: 011-389-233724
Fax: 011-389-233227
E-mail: [email protected]
Received: September 04, 2015 Accepted: October 15, 2015 Published: October 17, 2015
Citation: Jagetia GC, Mallikarjuna Rao KVN (2015) Hesperidin, A Citrus Bioflavonoid Reduces the Oxidative Stress in the Skin of Mouse Exposed to Partial Body γ-Radiation.Transcriptomics 3:111. doi:10.4172/2329-8936.1000111
Copyright: © 2015 Jagetia GC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Generation of reactive oxygen species (ROS) is one of the important and early events after exposure to ionizing radiations and this ROS production is responsible for the degenerative changes ensuing irradiation. An attempt has been made to modulate the radiation induced-ROS by hesperidin (hesperitin-7-rhamnoglucoside), a bioflavonoid in the wounded skin of irradiated mouse. The lower half of the animals was shaved and the animals were orally administered or not with 100 mg/kg body weight of hesperidin before exposure to 6 Gy of partial body gamma-radiation. The activities of glutathione peroxidase, superoxide dismutase and glutathione concentration as well as lipid peroxidation were estimated in the skin of mouse at 0, 1.5, 3, 6, 12, 24 and 48 h post-irradiation. Irradiation of mouse to 6 Gy caused a significant depletion in the activities of glutathione peroxidase, superoxide dismutase as well as glutathione concentration. Exposure of mouse to 6 Gy resulted in a significant elevation in lipid peroxidation when compared to the base line levels of lipid peroxidation. Administration of hesperidin before hemi- body exposure to 6 Gy γ-rays significantly raised the activities of glutathione peroxidase, superoxide dismutase and glutathione concentration, whereas hesperidin pretreatment caused a significant reduction in the radiation induced lipid peroxidation. The present study demonstrates that hesperidin pretreatment reduces the radiation induced oxidative stress in the irradiated wounds of mouse and may be useful paradigm to reduce the radiation-induced oxidative stress before or after surgery.

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