alexa Hexamminecobalt (III) Chloride as a Broad-Spectrum Antiviral Complex | OMICS International | Abstract
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Research Article

Hexamminecobalt (III) Chloride as a Broad-Spectrum Antiviral Complex

Eddie L. Chang1*, Gene G. Olinger2, Lisa E. Hensley2, Calli M. Lear2, Corinne E. Scully2, Marie K. Mankowski3, Roger G. Ptak3,
Dzung C. Thach4 and D. Andrew Knight5
1Center for Bio/Molecular Science and Engineering, 4555 Overlook Avenue SW, Washington, DC20375, USA
2United States Army Medical Research Institute of Infectious Diseases, Division of Virology, 1425 Porter Street, Frederick, Maryland, USA
3Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, MD, 21701, USA
4Laboratory of Infectious Diseases, National Institute of Allergies and Infectious Diseases, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
5Chemistry Department, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32922, USA
Corresponding Author : Dr. Eddie L. Chang
Center for Bio/Molecular Science and Engineering
4555 Overlook Avenue SW, Washington, DC20375, USA
Tel: (202) 404-6057
Fax: (202) 767-9511
E-mail: [email protected]
Accepted April 21, 2011; Published April 25, 2011
Citation: Chang EL, Olinger GG, Hensley LE, Lear CM, Scully CE, et al. (2011) Hexamminecobalt (III) Chloride As a Broad-Spectrum Antiviral Complex. J Antivir Antiretrovir 3: 020-027. doi: 10.4172/jaa.1000030
Copyright: ©2011 Chang EL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Metal ion complexes have the potential to form novel types of antiviral compounds, due to their ability to form octahedral and square-planar molecular geometries and their intrinsic charge density. Previously it has been shown that hexamminecobalt(III) chloride (Cohex) has antiviral properties against Sindbis virus (SINV) and adenovirus. Here, we report that Cohex also exhibits activities against two isolates of human immunodeficiency virus (HIV) and the Zaire Ebola (ZEBOV) strain expressing green fluorescent protein (GFP). The therapeutic indices for antiviral activity against the HIV isolates were similar to that found for SINV. Cohex was also effective in decreasing the host translation of viral GFP in four different cell-lines infected with ZEBOV. Toxicity studies in mice found no deleterious effects at up to 8 mg/kg. The 8 mg/kg concentration also prolonged survival of mice infected with ZEBOV. These results point to the potential of Cohex as a new type of broad-spectrum antibiotic compounds.

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