HIF-1 is the Commander of Gateways to CancerNagy MA*
Department of Chemistry, College of Science, Beni-Suef University, Beni-Suef, Egypt
- *Corresponding Author:
- Dr. Nagy MA
Department of Chemistry
College of Science
Tel: +20862375623, +20175011129
E-mail: [email protected]
Received date: October 02, 2010; Accepted date: November 13, 2010;; Published date: December 15, 2010
Citation: Nagy MA (2011) HIF-1 is the Commander of Gateways to Cancer. J Cancer Sci Ther 3: 035-040. doi: 10.4172/1948-5956.1000054
Copyright: © 2011 Nagy MA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and adapting of cells to changes in the O2 level, which is essential for their viability. An increased activity is recognized in the majority of clinical relevant hypoxic/ischemic episodes and human cancers .HIF-1 is considered a central regulator of the adaptation response of cancer cells to hypoxia that makes it a therapeutic target in solid tumors. In this article, the biochemical pathways that are regulated by HIF-1 and the factors that regulate HIF-1 expression are briefly discussed .as targeting HIF-1, may selectively kill tumor cells that adapt to low O2 concentrations.