High Ester Pectin Based Formulation for Site Specific Delivery of 5-Fluorouracil in to Descending Colon
- *Corresponding Author:
- Francis Ayuka
University of Canterbury
Kirichwa Road, Off Argwings Kodhed Road
Kirichwa Apartments, Nairobi, Nairobi 00100, Kenya
E-mail: [email protected]
Received Date: November 01, 2014 Accepted Date: January 12, 2015 Published Date: January 15, 2015
Citation: Ayuka F, Barnett R (2015) Place Effects on Alcohol Consumption: A Literature Review. J Addict Res Ther 6:207. doi: 10.4172/2155-6105.1000207
Copyright: © 2015 Ayuka F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This research has investigated over different parameters and combined the additional anti-cancerous properties of high ester pectin based formulation, which exhibit almost negligible degradation by colonic bacteria. In present investigation compression coated tablets were prepared using high ester pectin derived from Mangifera indica fruit peel for colon specific delivery of 5-Fluorouracil. Pectin was extracted from dried fruit peel powder of Mangifera indica using water acidified with 0.2 M citric acid and further isolated with ethanol. For optimization of drug release in to descending colon tablets were prepared using two independent variables (concentration of pectin in compression coating and concentration of Eudragit L100 in enteric coating) at three levels. Drug releases were studied using different buffers without pectinase and with pectinase. Results showed maximum drug release into the colon can be achieved with batch F8 consisting 60% pectin concentration and 12.5% Eudragit L100 in enteric coating with less deviation with predicted response. It was also found that drug release from enteric coated tablets does not changed significantly in the presence of enzyme. Thus, combination of pharmacological activities of drug and high ester pectin along with site specificity of Eudragit L-100 has focused a new light towards the area of conventional dosage forms.