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ISSN: 2167-1095

Journal of Hypertension: Open Access
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Research Article

High Homocysteine Levels are Closely Associated with the Categories of Coronary Artery Diseases as well as Low Status of Folic Acid and Vitamin B12

Yan Ma1, Duanliang Peng1, Chenggui Liu2*, Huang Chen2 and Jun Luo1

1East Branch, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610101, China

2Department of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, Chongqing Medical University, Chengdu 610091, China

*Corresponding Author:
Chenggui Liu, M.D
1617 Ri Yue Avenue
Qingyang District Chengdu
610091 China
Tel: +8613808024436
E-mail: [email protected]

Received Date: June 01, 2016; Accepted Date: June 23, 2016; Published Date: June 30, 2016

Citation: Ma Y, Peng D, Liu C, Chen H, Luo J (2016) High Homocysteine Levels are Closely Associated with the Categories of Coronary Artery Diseases as well as Low Status of Folic Acid and Vitamin B12. J Hypertens 5:228. doi:10.4172/2167-1095.1000228

Copyright: © 2016 Ma Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD). Folic acid and vitamin B12 are two vital regulators in Hcy metabolic process. We evaluated the associations between Hcy and the categories of CAD as well as the levels of folic acid and vitamin B12.

Methods: Hcy, folic acid and vitamin B12 from 292 CAD patients, including 73 acute myocardial infarction (AMI), 116 unstable angina pectoris (UAP), 103 stable angina pectoris (SAP), and 100 non-CAD controls were measured, and the data were analyzed by SPSS software.

Results: Hcy concentrations of AMI patients were the highest, and UAP patients were second, and SAP patients were the third higher, which were significantly higher than controls (p<0.01). Compared to SAP patients, patients with AMI and UAP had higher Hcy levels with approximately average elevated (4-5) μmol/L, while SAP patients were more higher Hcy with approximately 8 μmol/L than controls. However, the levels of folic acid and vitamin B12 had opposite results, whose levels in AMI group had the lowest, while in controls had the highest. There were strongly moderate negative correlations between Hcy and folic acid (r=-0.67, p<0.001) and vitamin B12 (r=-0.56, p<0.001).

Conclusions: The present study confirms that high Hcy levels are closely associated with the categories of CAD as well as low status of folic acid and vitamin B12.

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