alexa High Level of CD4+CD25+CD127- Treg Cells in Donor Graft is Associated with a Low Risk of aGVHD after allo-HSCT for Children with Hematologic Malignancies
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Research Article

High Level of CD4+CD25+CD127- Treg Cells in Donor Graft is Associated with a Low Risk of aGVHD after allo-HSCT for Children with Hematologic Malignancies

Zhang Fang#, Zhu Hua#, Luo Changying, Wang Jianmin, Luo Chengjuan, Xu Kangli and Chen Jing*
Department of Pediatric Hematology/Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
#These authors contributed equally to this work
Corresponding Author : Jing Chen
Department of Pediatric Hematology/Oncology
Shanghai Children’s Medical Center
School of Medicine, Shanghai Jiao Tong University
Shanghai 200127, China
Fax: +86-21-58756539
E-mail: [email protected]
Received October 22, 2013; Accepted November 18, 2013; Published November 20, 2013
Citation: Fang Z, Hua Z, Changying L, Jianmin W, Chengjuan L, et al. (2013) High Level of CD4+CD25+CD127- Treg Cells in Donor Graft is Associated with a Low Risk of aGVHD after allo-HSCT for Children with Hematologic Malignancies. J Cell Sci Ther 4:148. doi: 10.4172/2157-7013.1000148
Copyright: © 2013 Fang Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Acute Graft-Versus-Host Disease (aGVHD) is the major problem for patient undergoing allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT). Previous study showed the significant role of CD4+CD25+ Treg cells in inhibiting aGVHD. This retrospective study of 50 children with hematological malignancies undergoing allo-HSCT investigated the influence of donor CD4+CD25+CD127- Treg cells on aGVHD. The proportion of Treg cells in graft is significantly higher in patient with grade 0-I aGVHD than in patients with grade II-IV aGVHD (3.08 ± 0.72% vs. 2.52 ± 0.86%, P=0.016). There was no significant difference on Treg cells proportion in graft between relapsed and non relapsed patients (3.20 ± 0.80% vs. 2.80 ± 0.81% P=0.549). CD4+CD25+CD127- Treg cells in donor graft can reduce the incidence of aGVHD after children received allo-HSCT without increasing the risk of relapse. Graft CD4+CD25+CD127- Treg cells level is a valuable biomarker to predict aGVHD.

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