alexa High Levels of DNA Fragmentation Observed in an Infertile Population Attending a Fertility Center are Related to Advanced Paternal Age
ISSN: 2375-4508

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

High Levels of DNA Fragmentation Observed in an Infertile Population Attending a Fertility Center are Related to Advanced Paternal Age

Javier García-Ferreyra1*, Rocio Romero2, Roly Hilario2 and Julio Dueñas-Chacón1,2
1FERTILAB Laboratory of Assisted Reproduction, Lima, Perú
2PROCREAR Fertility Center, Lima, Perú
*Corresponding Author : Javier García-Ferreyra, PhD
FERTILAB Laboratory of Assisted Reproduction
Av. San Felipe 1017
Lima 11, Perú
E-mail: [email protected]
Received September 20, 2012; Accepted October 20, 2012; Published October 23, 2012
Citation: García-Ferreyra J, Romero R, Hilario R, Dueñas-Chacón J (2012) High Levels of DNA Fragmentation Observed in an Infertile Population Attending a Fertility Center are Related to Advanced Paternal Age. J Fert In Vitro 2:113. doi: 10.4172/2165-7491.1000113
Copyright: © 2012 García-Ferreyra J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: To evaluate the effects of male aging on semen quality and DNA fragmentation in male infertility patients attending Andrology Laboratory at fertility center.
Methods: Semen samples of 217 infertile patients were analyzed using Computer-Assisted Semen Analysis (CASA). Sperm DNA fragmentation was measured by the sperm chromatin dispersion test.
Results: Subject’s ages ranged from 21 to 68 years. The mean age was 38.45 years. The patients were distributed into four groups: <30 years, 30-39 years, 40-49 years and ≥ 50 years. Parameters of volume, pH and concentration were similar in four evaluated groups (P: NS). An age-dependent increase in sperm DNA fragmentation was observed in four evaluated groups. The patients ≥ 40 years old had spermatozoa with fragmented DNA significantly higher compared to those patients from <30 years old and 30-39 years old (P<0.05). Percentages of morphologically normal spermatozoa in patients of ≥ 50 years old were significantly lower compared to those men from group 30-39 years old (P<0.05). Men older than 40 years old had percentages of sperm vitality significantly lower compared to men of 39 years old or less (P<0.05).
Conclusions: Sperm DNA fragmentation, progressive motility, and spermatozoa morphology are associated to advanced paternal age. However, volume, pH, and sperm concentration are not affected by male age.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords