alexa High Performance Liquid Chromatography, TLC Densitometry, Firstderivative and First-derivative ratio spectrophotometry for de-termination of Rivaroxaban and its alkaline Degradates in Bulk Powder and its Tablets | Abstract
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
Open Access

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Research Article

High Performance Liquid Chromatography, TLC Densitometry, Firstderivative and First-derivative ratio spectrophotometry for de-termination of Rivaroxaban and its alkaline Degradates in Bulk Powder and its Tablets

Lories IB1, Mostafa AA2 and Girges MA1*

1National Organization for Drug Control and Research, Gizza, Egypt

2Analytical Chemistry Department, Faculty of pharmacy, Cairo University, Kasr El-Aini St., Cairo, Egypt

*Corresponding Author:
Girges MA
National Organization for Drug Control and Research
Gizza, Egypt
E-mail: [email protected]

Received Date: July 23, 2013; Accepted Date: September 23, 2013; Published Date: September 26, 2013

Citation: Lories IB, Mostafa AA, Girges MA (2013) High Performance Liquid Chromatography, TLC Densitometry, First-derivative and First-derivative ratio spectrophotometry for de-termination of Rivaroxaban and its alkaline Degradates in Bulk Powder and its Tablets. J Chromatograph Separat Techniq 4:202. doi:10.4172/2157-7064.1000202

Copyright: © 2013 Lories IB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Four sensitive and selective stability indicating methods for the determination of rivaroxaban (RIV) were developed. Method a was an isocratic RP-HPLC, good resolution between peaks corresponding to the degradates from analyte was achieved on C18 column. The mobile phase is 1.2% w/v potassium dihydrogen phosphate pH 3.5 ± 0.2 and acetonitrile (70:30, v/v). The detection was carried out at 280 nm. Method B depends on quantitative densitometric determination of thin layer chromatography TLC of rivaroxaban in the presence of it’s degradates without any interference. The developing system was chloroform-isobutyl alcohol (50:50 v/v).The chromatogram was scanned at 280 nm. Method C was based on the first derivative (D1) measurement of the drug at 237.4 nm; zero contribution point of its alkaline degradates. Method D was based on the resolution of the drug and its alkaline degradates by first derivative ratio spectra (DD1 successfully applied for the determination of rivaroxaban in bulk powder, pharmaceutical formulation and in presence of its alkaline degradates. The obtained results were statistically analyzed and compared with those obtained by the reported method

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