alexa High Prevalence of Esophageal Acid Exposure in Very Low
ISSN: 2167-0897

Journal of Neonatal Biology
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Research Article

High Prevalence of Esophageal Acid Exposure in Very Low Birth Weight Infants Presenting or Not Bronchopulmonary Dysplasia: A Prospective Cross-Sectional Study

Thaís Mendes-Lopes1, José Dirceu Ribeiro2 and Maria Aparecida Mezzacappa3*
1 Child and Adolescent Healthcare Program, University ofCampinas School of Medicine-UNICAMP, Campinas/São Paulo/Brazil
2 Department of Pediatrics, University of Campinas School of Medicine-UNICAMP, Campinas/São Paulo/Brazil
3 Division of Neonatology, Department of Pediatrics, University of Campinas School of Medicine-UNICAMP,Campinas/São Paulo/Brazil
Corresponding Author : Maria Aparecida Mezzacappa
101 Alexander Fleming St. Cidade Universitária Zeferino Vaz
PO Box: 6081,13083-881, Campinas
São Paulo, Brazil
Tel: +55193521-9307
Fax: +55193521-9307
E-mail: [email protected], [email protected]
Received December 14, 2013; Accepted February 14, 2014; Published February 16, 2014
Citation: Mendes-Lopes T, Ribeiro JD, Mezzacappa MA (2014) High Prevalence of Esophageal Acid Exposure in Very Low Birth Weight Infants Presenting or Not Bronchopulmonary Dysplasia: A Prospective Cross-Sectional Study. J NeonatalBiol 3:127. doi:10.4172/2167-0897.1000127
Copyright: © 2014 Mendes-Lopes T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: A high frequency of treatment for gastroesophageal reflux disease is observed in neonates with Bronchopulmonary Dysplasia (BPD). The association between these illnesses is controversial. Objective: To determine the prevalence of reflux index ≥ 10%, in very low birth weight infants, presenting or not BPD, using esophageal pH monitoring.
Methods: A prospective cross-sectional study was conducted. Thirty-five newborns presenting BPD and 15 newborns not presenting BPD underwent distal esophageal pH monitoring during their stay in a university hospital neonatal unit. The frequency of symptoms and gastroesophageal reflux treatment was studied in both groups.
Results: The prevalence of reflux index ≥ 10% did not differ between groups presenting (65.7%) and not presenting BPD (93.3%); p=0.075. Symptoms attributable to gastroesophageal reflux occurred in 91.4% of newborns presenting BPD and in 73.3% of the group not presenting BPD. Antireflux treatment was introduced to 80% of the subjects presenting BPD and to 20% of patients who were not presenting BPD; (p<0.001).
Conclusions:There is a high prevalence of increased esophageal mucosal exposure to acid in very low birth weight infants presenting or not BDP. The symptoms attributable to gastroesophageal reflux are frequent in both groups; however, in very low birth weight infants, not presenting BPD, a clinical progression complicated by gastroesophageal reflux is less frequent. Nevertheless, BPD is associated with a higher frequency of gastroesophageal reflux treatment, the indication of any therapeutic modality must be cautious, and the laboratory investigation associated with a clinical evaluation may contribute to a reduction in the number of unnecessary treatment.

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