High Sensitive Troponin as Biomarker for Coronary Artery DiseaseRavi Kumar1 and M. Imteyaz Ahmad2*
- *Corresponding Author:
- M. Imteyaz Ahmad
Department of Biochemistry
PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, India
E-mail: [email protected]
Received date: January 27, 2017; Accepted date: February 24, 2017; Published date: February 27, 2017
Citation: Kumar R, Ahmad MI (2017) High Sensitive Troponin as Biomarker for Coronary Artery Disease. J Clin Exp Cardiolog 8:500. doi: 10.4172/2155-9880.1000500
Copyright: © 2017 Kumar R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
There are various cardiac biomarkers available for diagnosis and stratification of patients with acute coronary syndrome but only few are cardiospecific and sensitive. Troponins are protein molecules that are part of cardiac and skeletal muscle. Smooth muscle cells do not contain troponins. There are three subunits of troponin T, I and C subunits. Cardiac troponins are known to increase on myocardial cell damage leading to myocardial necrosis. The kinetic pattern of release of troponin is known. The technological advancements in Immunoassay has led to improvement in the limit of detection, (LoD) Limit of quantitation (LoQ) and cut off detection limits. There are decreases in false positive cases due to antihuman antibodies use of sandwich fifth generation Troponin T immunoassay. Recently the troponin T fifth generation by (Roche diagnostics) is approved by US-FDA. The cutoffs detections and positive 99th percentile of reference population cutoffs has to be established by verification of manufacturers reference cutoff s limits. The delta change value after serial measurements of suspected patients with symptoms of AMI leads to diagnosis.