High SYNTAX Score and Long-Term Outcome Following Percutaneous Coronary Intervention with Drug-Eluting Stents: Insights from the LEADERS Trial
Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
- *Corresponding Author:
- Wail Nammas
Department of Cardiology, Faculty of Medicine
Ain Shams University. Abbassia, Cairo, Egypt
Tel: +2 122 4063718
Fax: +2 2 24820416
E-mail: [email protected]
Received Date: October 20, 2012; Accepted Date: October 22, 2012; Published Date: October 24, 2012
Citation: Nammas W (2013) High SYNTAX Score and Long-Term Outcome Following Percutaneous Coronary Intervention with Drug-Eluting Stents: Insights from the LEADERS Trial. Transl Med 3:e112. doi: 10.4172/2161-1025.1000e112
Copyright: © 2013 Nammas W. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Caveolae are flask-like invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the marker protein caveolin and the coat protein cavin. In cardiomyocytes, multiple signaling molecules are concentrated and organized within the caveolae to mediate signaling transduction. Recent studies suggest that caveolae and caveolaeassociated signaling molecules play an important role in protecting the myocardium against ischemia-reperfusion injury. For example, cardiac-specific overexpression of caveolin-3 has been shown to lead to protection that mimics ischemic preconditioning, while the knockout of caveolin-3 abolished ischemic preconditioning. In this review, we discuss the molecular mechanisms and signaling pathways that are involved in caveolae-mediated cardioprotection, and examine the potential for caveolae as a therapeutic target for pharmaceutical intervention to treat cardiovascular disease.