alexa High-Definition Optical Coherence Tomography in the Diagnosis of Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced Investigator | OMICS International | Abstract
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Research Article

High-Definition Optical Coherence Tomography in the Diagnosis of Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced Investigator

Li G1, Tietze JK2, Tao X1, Kulichova D2, Ruzicka T2, Berking C2 and Maier T2*

1Department of Physiotherapy, Jiangxi Provincial Dermatology Hospital, China

2Department of Dermatology and Allergology, Ludwig-Maximilian University of Munich, Munich, Germany

*Corresponding Author:
Tanja Maier
Department of Dermatology
Ludwig-Maximilian University
Frauenlobstr. 9-11, D-80337 Munich, Germany
Tel: +49-89-5160-6010
Fax: +49-89-5160-6110
E-mail: [email protected]

Received date: May 24, 2014; Accepted date: July 07, 2014; Published date: July 14, 2014

Citation: Li G, Tietze JK, Tao X, Kulichova D, Ruzicka T, et al. (2014) High- Definition Optical Coherence Tomography in the Diagnosis of Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced Investigator. J Clin Exp Dermatol Res 5:227. doi:10.4172/2155-9554.1000227

Copyright: © 2014 Li G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Histopathology is the gold standard in the diagnosis of basal cell carcinoma (BCC) but biopsies are invasive and often not the preferred diagnostic method for patients. In this context, non-invasive diagnostic imaging tools such as high definition optical coherence tomography (HD-OCT) have shown promising results in diagnosing BCC in real time, atraumatically and repeatedly.

Objective: To evaluate the sensitivity and specificity of HD-OCT in the diagnosis of BCC by an experienced versus an inexperienced investigator and describe typical features in common differential diagnosis of BCC.

Patients and methods: Forty three patients with clinical suspicion for BCC were included. The HD-OCT images were evaluated in a blinded manner by an experienced and inexperienced investigator. The results were compared to the histopathological diagnosis.

Results: Histopathology revealed 22 BCC, 10 fibrous papules of the face, 5 actinic keratoses, 3 intradermal nevi, 2 squamous cell carcinomas and 1 sebaceous hyperplasia. The sensitivity and specificity in diagnosing BCCs correctly by HD-OCT in the experienced investigator was 86.4% and 90.5%, respectively. In the inexperienced investigator the sensitivity and the specificity was 77.3% and 81.0%, respectively. There was a good inter-observer agreement found between experienced and inexperienced investigators.

Conclusion: HD-OCT can be used as auxiliary diagnostic tool in the evaluation and treatment of BCC even by inexperienced investigators.


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