alexa High-Expressed CXCR7 Contributes to CXCL12-Mediated Protection from Apoptosis in Lymphoma Cells
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

High-Expressed CXCR7 Contributes to CXCL12-Mediated Protection from Apoptosis in Lymphoma Cells

Dongsheng Xu1, 2, Xiaobei Deng2, Lisha Qiu4, Xiaoxiao Qian3, Yuqing Yan4, Tong Lu4 and Jianguo Wu1*

1State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan , PR China

2Center for Translational Neuro-degeneration and Regenerative Therapy, Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, PR China

3College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA

4Xuzhou Medical College, Xuzhou, Jiangsu, PR China

Corresponding Author:
Jianguo Wu
State Key Laboratory of Virology
College of Life Sciences
Wuhan University, Wuhan 430072 PR China
Tel: 862768754231
Email: [email protected]

Received date: October 08, 2015; Accepted date: April 16, 2016; Published date: April 20, 2016

Citation: Xu D, Deng X, Qiu L, Qian X, Yan Y, et al. (2016) High-Expressed CXCR7 Contributes to CXCL12-Mediated Protection from Apoptosis in Lymphoma Cells. J Mol Genet Med 10:208. doi:10.4172/1747-0862.1000208

Copyright: © 2016 Xu D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Viral genes may act as oncogenes and interact with intracellular proteins, which are related to oncogenesis and tumor growth. Autocrining CXCL12 in growing tumor tissue plays critical roles in modulating cell proliferation and survival through its receptor CXCR4 and CXCR7. Recently, a number of research reports indicated that CXCR7 displays high expression in many kinds of tumor tissues and cell lines and that high -expressed CXCR7 may be involved in cell survival and migration. To date, CXCR7’s biological function and signaling in cancer pathogenesis is unclear. In this study, we first found there are higher expression of CXCR7 in both lymphocyte nodes and EBV positive lymphoma cell line IB4. The results further suggested that high-expressed CXCR7 plays a role in CXCL12 mediated anti-apoptosis and inhibition of CXCR7 through CXCR7 inhibitor CCX771 significantly attenuated the function of CXCL12 on anti-apoptosis. Furthermore, we observed that CXCR7 inhibitor directly reduced protection of endogenous CXCL12 from apoptosis in EBV positive lymphoma cell line. Finally, the results revealed that CXCL12 activated CXCR7 trafficking to membrane and interaction of CXCR7 and β-arrestin-2 during anti-apoptosis process. The study suggested that the high expressed CXCR7 may have effect on anti-apoptosis and inhibitor of CXCR7 may become potential target for cancer therapy.

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