alexa High-Sensitivity Cardiac Troponin T is Associated with SYNTAX Score and Diabetes Mellitus in Patients with Stable Coronary Artery Disease | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

High-Sensitivity Cardiac Troponin T is Associated with SYNTAX Score and Diabetes Mellitus in Patients with Stable Coronary Artery Disease

Hakan Uçar*, Mustafa Gür, Taner Şeker, Onur Kaypaklı, Zafer Elbasan, Nermin Yıldız Koyunsever, Caner Türkoğlu, Betül Özaltun, Osman Kuloğlu, Gülhan Yüksel Kalkan, Durmuş Yıldıray Şahin, and Murat Çaylı
Adana Numune Training and Research Hospital, Department of Endocrinology and Metabolism, Adana/Turkey
Corresponding Author : Hakan Uçar
Department of Cardiology
Adana Numune Education and Research Hospital
Adana 01170, Turkey
Tel: 00905305240285
Fax: 00903223550315
E-mail: [email protected]
Received June 19, 2013; Accepted July 22, 2013; Published July 25, 2013
Citation: Uçar H, Gür M, Seker T, Kaypakli O, Elbasan Z, et al. (2013) High- Sensitivity Cardiac Troponin T is Associated with SYNTAX Score and Diabetes Mellitus in Patients with Stable Coronary Artery Disease. J Clin Exp Cardiolog 4:263. doi:10.4172/2155-9880.1000263
Copyright: © 2013 Uçar H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

High-sensitivity cardiac troponin T (hs-cTnT) and the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score are emerging as important prognostic markers in stable coronary artery disease (CAD). We aimed to investigate the relationship between hs-cTnT and extent and complexity of CAD assessed with STNTAX score. Measurements were obtained from 411 patients with stable CAD (Mean age=61.7 ± 9.9 years, male/female=247/164). The patients were divided into two groups according to the median hs-TnT value (hs-cTnTlow group<9.65 pg/ml and hs-cTnThigh group ≥ 9.65 pg/ml). SYNTAX score values were higher in hs-cTnThigh group compared with hs-cTnTlow group (p<0.05). Hs-cTnT was independently associated with SYNTAX score (β=0.661, p<0.001) and diabetes (β=0.107, p=0.031) in multiple linear regression analysis. The cutoff value of hscTnT obtained by the ROC curve analysis was 9.62 ng/L for the prediction of higher SYNTAX score. In multivariate logistic regression analysis, hs-cTnT, age, diabetes, creatinine and hs-CRP were an independent predictor for higher SYNTAX score. Despite very low circulating concentrations, changes in hs-cTnT concentrations are associated with extent and complexity of CAD and presence of diabetes in patients with stable CAD.

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