Hippocampal CA2 Region: A New Player in Social DysfunctionsXiang Mou*
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
- *Corresponding Author:
- Department of Molecular and Cellular Biology
Baylor College of Medicine, Houston, USA
E-mail: [email protected]
Received date: January 25, 2016; Accepted date: February 16, 2016; Published date: February 23, 2016
Citation: Mou X (2016) Hippocampal CA2 Region: A New Player in Social Dysfunctions. J Neurol Neurophysiol 7:357. doi:10.4172/2155-9562.1000357
Copyright: © 2016 Mou X. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
For social species, normal social cognitive functions are essential for individuals to survive in a social group. Various neuropsychiatric disorders, including schizophrenia, autism and bipolar disorder are characterized by the impairments in social cognition. The hippocampus has been at the forefront of research in learning and memory for several decades. Hippocampal dysfunction contributes to learning and memory impairments as well as a range of social dysfunctions. However, precise contributions of different hippocampal sub-regions to differential aspects of cognitive functions remain unclear. This review first describes several key features of social abnormalities related to neuropsychiatric disorders, and then introduces the behavioral tasks used in animal models to assess each feature. Second, it gives a basic description of CA2 anatomy followed by an overview of its known functions. Third, it highlights a number of recent findings that associate the abnormalities of the hippocampal CA2 area and social dysfunctions in both animal models and human patients.