alexa Hippocampal Neuron Protecting Effect of Propofol Against Hypoxia/Reoxygenation via Inducing Nerve Growth Factor
ISSN: 2161-1025

Translational Medicine
Open Access

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Research Article

Hippocampal Neuron Protecting Effect of Propofol Against Hypoxia/Reoxygenation via Inducing Nerve Growth Factor

Ya-Ni Feng1*, Qiang Shi2, Hong Ma1 and Jun Fang3,4*

1 Department of Anesthesiology, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, P. R. China

2 Department of Neurosurgery, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, P. R. China

3 Department of Toxicology, School of Public Health, Anhui Medical University, 81th Meishan Road, Hefei City, Anhui Province, P. R. China

4 Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Science, Sojo University, Kumamoto, Japan

*Corresponding Author:
Ya-Ni Feng
Department of Anesthesiology
The First Affiliated Hospital
China Medical University
Shenyang, Liaoning 110005, P. R. China
Tel: 86-24-83282444
Fax: 86-24-83282444
E-mail: [email protected]

Jun Fang
Laboratory of Microbiology and Oncology
Faculty of Pharmaceutical Science
Sojo University, Kumamoto, Japan
Tel: +81-96-326-4137
Fax: +81-96-326-5048
E-mail: [email protected]

Received Date: December 13, 2013; Accepted January 26, 2014; Published Date: January 31, 2014

Citation: Feng YN, Shi Q, Ma H, Fang J (2014) Hippocampal Neuron Protecting Effect of Propofol Against Hypoxia/Reoxygenation via Inducing Nerve Growth Factor. Transl Med 4:123. doi:10.4172/2161-1025.1000123

Copyright: © 2013 Feng YN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Propofol, an intravenous anesthetic agent, exhibits neuroprotective effects against cerebral ischemia–reperfusion injury. Here, we used a model of Hypoxia/Re-Oxygenation (H/R) injury to examine the hippocampal neuroprotective effect of propofol, and explored the role of Nerve Growth Factor (NGF) and NGF receptor TrkA in this action. Rat hippocampal neuron cells were subjected to H/R with different concentrations propofol, the viability and apoptosis of the cells were then determined by MTT assay and annexin V flow cytometry, respectively. Meanwhile, expression of NGF and TrkA were measured by RT-PCR and Western blot. The results showed that H/R significantly reduced viability and increased apoptosis of cultured hippocampal neuron cells, along with the significantly decreased expressions of NGF and TrkA. However, pretreatment of propofol recovered the expressions of NGF and the receptor TrkA, resulting in significantly decreased H/R-induced neurotoxicity. C-Jun N-terminal kinase (JNK) inhibitor suppressed the effect of propofol on the NGF expression, and the TrkA was decreased by PD98059, the Erk1/2 signal blocker. Administration of TrkA inhibitor altered the neuroprotective effect of propofol. These findings suggested the potential of propofol for protecting hippocampal neuron against H/R through at least partly, NGF/TrkA signaling pathway.

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