alexa Histomorphometric Analysis of the Alveolar Bone for Two Weeks after Bone Morphogenetic Protein Transfer | OMICS International| Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
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  • Research Article   
  • J Cytol Histol 2017, Vol 8(5): 486
  • DOI: 10.4172/2157-7099.1000486

Histomorphometric Analysis of the Alveolar Bone for Two Weeks after Bone Morphogenetic Protein Transfer

Mariko Kawai* and Kiyoshi Ohura
Department of Pharmacology, Osaka Dental University, Osaka, Japan
*Corresponding Author : Mariko Kawai, Department of Pharmacology, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata-City, Osaka, 573-1121, Japan, Tel: +81-72-864-3058, Fax: +81-72-864-3158, Email: [email protected]

Received Date: Nov 01, 2017 / Accepted Date: Nov 20, 2017 / Published Date: Nov 30, 2017


Alveolar bone regeneration therapy is critical to retain the teeth and proper occlusion. Currently, alveolar bone loss is treated surgically using bone grafts or artificial bone, both of which carry the risk of complications, such as post-operative infection. A new, non-surgical therapy would help to improve patient safety levels and treatment success. Alveolar bone is always proceeding remodelling, and this makes it difficult for the clinicians and researchers to evaluate alveolar bone tissues after some regenerative treatments. In our previous studies, we developed a system for bone regeneration using non-viral bone morphogenetic protein (BMP) gene-expression plasmid vectors and in vivo electroporation for the ectopic bone formation in rat skeletal muscles. Here, we used bone morphometric analyses using calcein and tetracycline labelling in rats to evaluate changes in alveolar bone with our BMP gene-transfer system. We concluded that BMP-2/7 gene transfer to the periodontal tissues was an optimal therapy for the alveolar bone regeneration.

Keywords: Alveolar bone; Histomorphometric analysis; Bone labelling; Gene therapy

Citation: Kawai M, Ohura K (2017) Histomorphometric Analysis of the Alveolar Bone for Two Weeks after Bone Morphogenetic Protein Transfer. J Cytol Histol 8: 486. Doi: 10.4172/2157-7099.1000486

Copyright: © 2017 Kawai M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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