alexa Histones: Controlling Tumor Signaling Circuitry
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Review Article

Histones: Controlling Tumor Signaling Circuitry

Manoela D. Martins1 and Rogerio M. Castilho2*
1Department of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
2Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA
Corresponding Author : Rogerio M. Castilho
Laboratory of Epithelial Biology
Department of Periodontics and Oral Medicine
University of Michigan-1011 N University Ave
Room 3323B, Ann Arbor, MI, 48109-1078, USA
Tel: (734) 647-2150
E-mail: [email protected]
Received June 28, 2013; Accepted July 22, 2013; Published July 29, 2013
Citation: Martins MD, Castilho RM (2013) Histones: Controlling Tumor Signaling Circuitry. J Carcinogene Mutagene S5:001. doi: 10.4172/2157-2518.S5-001
Copyright: © 2013 Martins MD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Epigenetic modifications constitute the next frontier in tumor biology research. Post-translation modification of histones dynamically influences gene expression independent of alterations to the DNA sequence. These mechanisms are often mediated by histone linkers or by proteins associated with the recruitment of DNA-binding proteins, HDACI and II interacting proteins and transcriptional activators, coactivators or corepressors. Early evidence suggested that histones and their modifiers are involved in sophisticated processes that modulate tumor behavior and cellular phenotype. In this review, we discuss how recent discoveries about chromatin modifications, particularly histone acetylation, are shaping our knowledge of cell biology and our understanding of the molecular circuitry governing tumor progression and consider whether recent insights may extend to novel therapeutic approaches. Furthermore, we discuss the latest oncogenomic findings in Head and Neck Squamous Cell Carcinoma (HNSCC) from studies using Next Generation Sequencing (NGS) technology and highlight the impact of mutations identified in histones and their modifiers


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