Histopathological Changes in Placenta of Rat Induced by Levtricetam
- Corresponding Author:
- Huda Abdulwadood Omer
Faculty of Medicine and Health Sciences
Forensic Medicine and Toxicology
Al-Mansorrha, Aden, Aden
Al-Mansorrha, Yemen, 00967
E-mail: [email protected]
Received October 19, 2014; Accepted November 25, 2014; Published December 03, 2014
Citation: Omer HA, Kutb MA, Kaatabi HA (2014) Histopathological Changes in Placenta of Rat Induced by Levtricetam. Int J Neurorehabilitation 1:134. doi:10.4172/2376-0281.1000134
Copyright: © 2014 Omer HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and objectives: Levetiracetam (LEV) is an established second-generation antiepileptic drug. Its use in women with epilepsy of child-bearing potential is a delicate balance between seizure control and adverse effects to the fetus. This study has been designed to evaluate the histopathological effect of levetiracetam in different doses (Therapeutic dose & ¼ LD50), on the placenta of experimental rats.
Design and Setting: This study is a randomized single blind control trail conducted from January 2009-December2009.Materials and Methods: Placentas were collected for microscopic examination on day 20 of gestation after rat’s scarification.
Results: The placenta showed neither significant reduction in weight nor any overt anomaly compared to control group. Histological examination of the treated groups showed structural changes mainly in the dose of 1/4 LD50. Decidual necrosis, decrease trophospongium area, fibrinoid deposit, necrosis of labyrinth, vascular congestion and hemorrhage were observed. The results suggested that levetiracetam induced dose dependent changes in the structure of placenta.
Conclusions: Therefore, levetiracetam in therapeutic dose can be used safely during pregnancy. However, its safety showed be established in a large scale randomized study with long term follow-up.