Histopathological Study of Time Course Changes in Obstructed Lymphatic Vessels in Rats
Fusa Ogata* and Isao Koshima
Plastic and Reconstructive Surgery, Graduated School of Medicine University of Tokyo, Japan
- *Corresponding Author:
- Fusa Ogata
Department of Plastic and Reconstructive Surgery
University of Tokyo, 7-3-1
Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
E-mail: [email protected]
Received date: June 18, 2013; Accepted date: August 22, 2013; Published date: August 30, 2013
Citation: Ogata F, Koshima I (2013) Histopathological Study ff Time Course Changes in Obstructed Lymphatic Vessels in Rats. Surgery Curr Res 3:143. doi:10.4172/2161-1076.1000143
Copyright: © 2013 Ogata F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Lymphedema is a progressive accumulation of protein-rich fluid in the interstitial space of the skin, resulting from an anatomic or functional obstruction in the lymphatic system. Currently effective therapies for this disease are little known. We have been using surgical treatment, lymphaticovenular anastomoses, for patients and experienced some cases that improved dramatically and did not require the use of stockings and massages for more than ten years after surgery.
Methods: We investigated transitional morphological changes in lymphatic obstructed models by electron microscopy with focus on lymphatic smooth muscle cells after experimentally lymphatic vessel occlusion.
Results: We observed interesting dramatic alterations in obstructed lymphatic smooth muscle cells at different times.
Conclusion: These results suggest possibilities for the diversity of lymphatic smooth muscle cells.