alexa HIV Associated Chronic Obstructive Pulmonary Disease in Nigeria
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

HIV Associated Chronic Obstructive Pulmonary Disease in Nigeria

Maxwell O Akanbi1*, Babafemi O Taiwo2, Chad J Achenbach2, Obianuju B Ozoh3, Daniel O Obaseki4, Halima Sule5, Oche O Agbaji1and Christiana O Ukoli1

1Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria

2Northwestern University Chicago, USA

3Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria

4Department of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria

5Department of Family Medicine, Jos University Teaching Hospital, Nigeria

*Corresponding Author:
Maxwell O Akanbi
Department of Medicine
Jos University Teaching Hospital Jos
Plateau State, Nigeria
Tel: 002348033466771
E-mail: [email protected]

Received date: March 18, 2015; Accepted date: April 27, 2015; Published date: May 05, 2015

Citation: Akanbi MO, Taiwo BO, Achenbach CJ, Ozoh OB, Obaseki DO, et al. (2015) HIV Associated Chronic Obstructive Pulmonary Disease in Nigeria. J AIDS Clin Res 6:453. doi:10.4172/2155-6113.1000453

Copyright: ©2015 Akanbi MO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: To determine the prevalence and risk factors for chronic obstructive pulmonary disease (COPD) among HIV-infected adults in Nigeria.

Design: Cross-sectional study.

Methods: HIV-infected adults aged ≥ 30 years with no acute ailments accessing care at the antiretroviral therapy clinic of Jos University Teaching Hospital were enrolled consecutively. Participants were interviewed to obtain pertinent demographic and clinical information, including exposure to risk factors for COPD. Post-bronchodilator spirometry was carried out. HIV related information was retrieved from the clinic medical records. COPD case-definition was based on the Global Initiative for Obstructive Lung Disease (GOLD) criteria using post-bronchodilator FEV1/FVC <0.7. COPD prevalence was also calculated using the lower limit of normal for FEV1/FVC criteria (LLN) from the European Respiratory Society normative equation. Factors associated with COPD were determined using logistic regression models.

Results: Study population comprised 356 HIV infected adults with mean age of 44.5 (standard deviation, 7.1) years and 59% were female. The mean time elapsed since HIV diagnosis was 7.0 (SD, 2.6) years and 97.5% of the respondents were on stable ART with virologic suppression present in 67.2%. Prevalence of COPD were 15.4% (95% confidence interval [CI] 11.7-19.2), 12.07% (95% CI 8.67-15.48), 22.19% (95% CI 18.16-26.83) using GOLD, ERS LLN and GLI LLN diagnostic criteria respectively. In multivariate analyses adjusting for gender, exposure to cigarette smoke or biomass, history of pulmonary tuberculosis, use of antiretroviral therapy, current CD4 T-cell count and HIV RNA, only age > 50 years was independently associated with COPD with OR 3.4; 95% CI 1.42-8.17 when compared to ages 30-40 years.

Conclusion: HIV-associated COPD is common in our population of HIV patients.

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