HIV Co-Infection with Hepatotropic Viruses and Mycobacterial Tuberculosis
- *Corresponding Author:
- Okeke TC
Department of Obstetrics & Gynaecology
University of Nigeria Teaching Hospital UNTH
E-mail: [email protected]
Received Date: June 30, 2013; Accepted Date: July 29, 2013; Published Date: August 03, 2013
Citation: Okeke TC, Anyaehie BU (2013) HIV Co-Infection with Hepatotropic Viruses and Mycobacterial Tuberculosis. J AIDS Clin Res 4:229. doi:10.4172/2155-6113.1000229
Copyright: © 2013 Okeke TC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HIV Co-infection complicates the natural history, clinical course, therapy and management for HIV. The individuals affected represent a treatment challenge fraught with controversies associated with drug resistance, cross-resistance, hepatotoxicity and suboptimal response. This is a descriptive review of co-infection in HIV positive individuals. Studies have shown that HIV co-infection accelerates the natural course of hepatotropic viruses and increased risk of liver cirrhosis, hepatocellular carcinoma, and decompensated liver disease in co-infected individuals. Studies have equally shown increased risk of progression to acquired immunodeficiency syndrome AIDS and AIDS-related death among HIV/HCV co-infected persons and HCV may affect the management of HIV infection, increasing the incidence of liver toxicity associated with antiretroviral regimens. Dual HBV/ HCV co-infection tend to have more severe liver cirrhosis and hepatitis decompensation, and a higher incidence of hepatocellular carcinoma. HIV is a strong risk factor for TB. High prevalence rates are significantly correlated with high TB incidence rates. Tuberculosis equally accelerates the progression of disease in HIV.
Co-infection with HIV is a growing public health problem worldwide. There is need for enlightenment and further researches to highlight the importance of public health follow-up and reduction measures for HIV co-infected individuals in order to prevent subsequent infections.