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HLA Class I and II Binding Promiscuity of the T-cell Epitopes in Putative Proteins of Hepatitis B Virus | OMICS International | Abstract
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
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Research Article

HLA Class I and II Binding Promiscuity of the T-cell Epitopes in Putative Proteins of Hepatitis B Virus

Vijai Singh1, Indramani2, Dharmendra Kumar Chaudhary2, Pallavi Somvanshi1*
1Bioinformatics Centre, Biotech Park, Sector-G Jankipuram, Lucknow-226021
2National Bureau of Fish Genetic Resources, Lucknow-226002
Corresponding Author : Dr. Pallavi Somvanshi,
Bioinformatics Centre, Biotech Park, Sector –G
Jankipurum, Lucknow (India)
Phone : +91 522 4012078
Email  : [email protected]
Received January 20, 2009; Accepted February 25, 2009; Published February 27, 2009
Citation: Vijai S, Indramani, Dharmendra KC, Pallavi S (2009) HLA Class I and II Binding Promiscuity of the T-cell Epitopes in Putative Proteins of Hepatitis B Virus. J Comput Sci Syst Biol 2:069-073. doi:10.4172/jcsb.1000018
Copyright: © 2009 Vijai S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Hepatitis B virus is a human infectious disease universally caused by the hepatitis B virus. Its genome size is 3.215 kb. Immunoinformatics tools have been used to predict the epitopes from seven putative protein viz. polymerase, large-S- and middle –S- Protein, S and X- protein, Precore/Core Protein, Core and E- antigen. Total 50 epitopes were predicted for MHC class I and 55 epitopes for class II MHC molecules. These epitopes showed highest binding score at optimum threshold. Epitopes may use as an antigen for diagnosis and also might be helpful for designing peptide based subunit vaccine against Hepatitis B virus.

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