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HLA Class II (DRB1 and DQB1) Polymorphism in Omanis | OMICS International | Abstract
ISSN: 2161-0991

Journal of Transplantation Technologies & Research
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Research Article

HLA Class II (DRB1 and DQB1) Polymorphism in Omanis

Khalid Rashid Albalushi1,2, Mohamed Hichem Sellami3*, Hamad AlRiyami2, Mathew Varghese2, Mohamed Kamel Boukef1 and Slama Hmida1,3

1Faculty of Pharmacy, University of Monastir, Tunisia

2Department of Genetics, Sultan Qaboos University. Tunisia

3Department of Immunohaematology, National Blood Transfusion Centre of Tunis, Tunisia

*Corresponding Author:
Mohamed Hichem Sellami
Department of Immuno-Haematology
The National Blood Transfusion Centre of Tunis
13 Rue Djbel Lakhdar-Bab Saadoun 1006
Tunis-Tunisia
Tel: +216 71.561.920, +216 71.573.884
Fax: + 216 71.562.957
E-mail: [email protected]

Received Date: Jun 13, 2014,Accepted Date: July 25, 2014; Published Date: July 27, 2014

Citation: Albalushi KR, Sellami MH, AlRiyami H, Varghese M, Boukef MK, et al. (2014) HLA Class II (DRB1 and DQB1) Polymorphism in Omanis. J Transplant Technol Res 4: 134. doi: 10.4172/2161-0991.1000134

Copyright: © 2014 Albalushi KR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The HLA class II polymorphism of 254 healthy unrelated Omanis was analyzed by PCR-SSP method, and the detected frequencies were compared to those reported in 20 other populations. The most frequent HLA class II DRB1 alleles were DRB1*16, DRB1*03 and DRB1*15 with frequencies of 0.315, 0.224 and 0.106 respectively, while the most frequent DQB1 alleles were DQB1*05 and DQB1*02 with frequencies of 0.366 and 0.283 respectively. The haplotype analysis revealed that DRB1*03-DQB1*02 was the most common HLA class II haplotype with linkage disequilibrium (a frequency of 0.206). Compared with other populations, our result, deduced from the analysis of genetic distances and the construction of neighbour joining dendrogram, indicates that Omanis are related to Mediterranean and West-Asian populations. This fact might be explained by several historic and socio-geographic factors if we consider on the long history of this population.

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