alexa HLA: Facts and Findings | OMICS International | Abstract
ISSN: 2329-8936

Transcriptomics: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Editorial

HLA: Facts and Findings

Tapas Kumar Chaudhuri* and Pokhraj Guha
Department of Zoology, Cellular Immunology Laboratory, University of North Bengal, Raja Rammohunpur, Siliguri, West Bengal, India
Corresponding Author : Tapas Kumar Chaudhuri
Department of Zoology, Cellular Immunology Laboratory
University of North Bengal, Raja Rammohunpur, Siliguri
West Bengal, India, 734013
Tel: 9434377127
E-mail: [email protected]
Received: August 28, 2015 Accepted: August 31, 2015 Published: September 03, 2015
Citation: Chaudhuri TK, Guha P (2015) HLA: Facts and Findings. Transcriptomics 3:e112. doi:10.4172/2329-8936.1000e112
Copyright: © 2015 Chaudhuri TK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google

Abstract

Human Major Histocompatibility Complex also known as Human Leukocyte Antigen (HLA) system is an extended portion of human genome spanning a region of about 4000 Kb on the short arm of chromosome 6 between 6p21.31 and 6p21.32.1. This region contains a large number of polymorphic genes with variable expression and function which are arranged close together and are generally inherited as a haplotype. These genes have been grouped into different clusters based on their structural and functional characteristics namely: Class I, II and III. Due to their diploid nature, an individual inherits two alleles of each HLA loci, one each from either parent. Furthermore, due to very low recombination frequency (less than 1%), a complete set of alleles on the same chromosome is usually inherited as a haplotype. Approximately 150 billion or even more genotypic combinations are possible in the HLA system. According to Klein, such a polymorphism is not only advantageous for an individual, but also enhances the survivality of the species surrounded by plethora of pathogens.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version