alexa HLA-B27 and an Electrocardiographic Peculiarity
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

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Research Article

HLA-B27 and an Electrocardiographic Peculiarity

James Ker*
Department of Physiology, University of Pretoria, South Africa
Corresponding Author : Professor James Ker
MRCP, PhD, FESC, FACC, Department of Physiology
University of Pretoria, South Africa
Tel: +2712-3430078
Fax: +2712-3430079
E-mail: [email protected]
Received July 31, 2011; Accepted September 03, 2011; Published September 06, 2011
Citation: Ker J (2011) HLA-B27 and an Electrocardiographic Peculiarity. J Clinic Experiment Cardiol 2:149. doi:10.4172/2155-9880.1000149
Copyright: © 2011 Ker J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Introduction: An increased cardiovascular mortality has been described in patients with spondyloarthropathies due to HLA-B27. Numerous cardiovascular afflictions are currently known to be associated with HLA-B27. These include aortic root dilation, aortic regurgitation, mitral regurgitation, myocarditis, heart failure, pericarditis, pericardial effusion, atrioventricular conduction block and more recently, the presence of J-waves. Materials and methods: 48 HLA-B27 positive patients (23 men and 25 women) were included in this observational study. A 12-lead electrocardiogram and a signal-averaged electrocardiogram was recorded in every patient in order to detect any possible J-waves and ventricular late potentials respectively. Results: 27 out of these 48 patients demonstrated a visible J-wave in the inferolateral leads. It was revealed that there is a likelihood ratio of 11.386 (p=0.00074) to demonstrate a visible J-wave if the duration of low-amplitude signals is less than 30 ms. Conclusion: HLA-B27 positive patients has a high incidence of inferolateral cardiac J-waves. There is a high probability of demonstrating such a J-wave on the 12-lead electrocardiogram if the duration of ventricular late potentials is less than 30 ms. The possible mechanisms of this electrocardiographic paradox is discussed.

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