alexa Holoprosencephaly and Dandy Walker Malformation: A Rare Association Presenting as Birth Asphyxia
ISSN: 2167-0897

Journal of Neonatal Biology
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Short Communication

Holoprosencephaly and Dandy Walker Malformation: A Rare Association Presenting as Birth Asphyxia

Rashmita Nayak1 and Suvendu Mohapatra2*
1Department of Pediatrics, S.C.B Medical College, Cuttack, Odisha, India
2Department of Radiology S.C.B Medical College, Cuttack, Odisha, India
Corresponding Author : Dr. Suvendu Mohapatra M.D
Senior Resident, Department Of Radiology
S.C.B Medical College & Hospital, Cuttack, Odisha, 753007, India
Tel: +09861412800
Fax: +916742390674
E-mail: [email protected]
Received April 30, 2014; Accepted June 03, 2014; Published June 05, 2014
Citation: Nayak R, Mohapatra S (2014) Holoprosencephaly and Dandy Walker Malformation: A Rare Association Presenting as Birth Asphyxia. J Neonatal Biol 3:146. doi:10.4172/2167-0897.1000146
Copyright: © 2014 Nayak R, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Holoprosencephaly a type of neuronal migration defect may present as birth asphyxia and is usually associated with other central nervous system and/ or systemic malformations. But its association with Dandy Walker cyst is rare.
Case characteristics: In a 6 month old male child presenting with global developmental delay since birth and refractory seizures with microcephaly and hypotonic extremities all attributed as birth asphyxia sequel neuroimaging revealed holoprosencephaly and dandy walker malformation, two major malformations in one child.
Observation: Till nine months child was considered to be post asphyxia sequel due to global developmental delay and seizures but only neuroimaging pointed towards the malformations. Computed tomography revealed presence of Dandy Walker malformation with semilobar holoprosencephaly which was the reason for the refractory seizures and thus had guarded prognosis.
Outcome: On three months follow up the child continued to have refractory seizures and delayed development. Message: Central nervous system malformations may be symptomatic from birth and may present with poor apgar score at birth, refractory seizures and global developmental delay due to which they may be confused with birth asphyxia. Timely neuroimaging can make the diagnosis and thus the prognosis.

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