alexa Homocysteine and Parkinsons Disease: A Complex Relation
ISSN: 2329-6895

Journal of Neurological Disorders
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Homocysteine and Parkinsons Disease: A Complex Relationship

Gayle Helane Doherty*
School of Psychology and Neuroscience, University of St Andrews, Scotland, UK
Corresponding Author : Gayle Helane Doherty
School of Psychology and Neuroscience
University of St Andrews
Bute Building
West Burn Lane, St Andrews
Fife, KY16 9TS, UK
Tel: +44 1334 463611
E-mail: [email protected]
Received February 20, 2013; Accepted March 22, 2013; Published March 25, 2013
Citation: Doherty GH (2013) Homocysteine and Parkinson’s Disease: A Complex Relationship. J Neurol Disord 1:107. doi: 10.4172/2329-6895.1000107
Copyright: © 2013 Doherty GH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

The scientific literature contains a multitude of papers linking homocysteine to poor health. Elevated homocysteine levels have been linked to cardiovascular disorders, an increased risk of fractures in the elderly and to neurological conditions. Parkinson’s Disease is the second most prevalent neurodegenerative disorder after Alzheimer’s disease. It is characterised primarily by the loss of dopaminergic neurons of the substantia nigra pars compacta leading to movement disorders. In vitro data has demonstrated a marked deleterious effect of homocysteine on the neurons that die in Parkinson’s. Yet population-based studies reveal mixed results as to whether or not elevated homocysteine is a risk factor for Parkinson’s development. Nonetheless it is well known that the use of levodopa to alleviate symptoms of Parkinson’s leads to hyperhomocysteinemia, and that patients with the highest levels of homocysteine deteriorate faster than those with lower homocysteine titres. Thus homocysteine is of clinical significance for Parkinson’s patients and a fuller understanding of its effects on neuronal biochemistry and function will lead to better strategies to maintain quality of life for Parkinson’s sufferers.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords