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Homology Modelling of Hypoxanthinandndash;Guanine Phosphoribosyltransferase, Enzyme Involved in Salvage Pathway of Purine Metabolism | OMICS International | Abstract
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
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Research Article

Homology Modelling of Hypoxanthin–Guanine Phosphoribosyltransferase, Enzyme Involved in Salvage Pathway of Purine Metabolism

Jyotsna Choubey1*, Ashish Patel1, Sheetal Khatri1, Ruby Dewangan1, Shailendra Kumar Gupta2, M.K. Verma1

1Sub -DIC Bioinformatics center, NIT Raipur (C.G.) 492010, India

2Indian Institute of Toxicology Research, Lucknow (U.P.), India

*Corresponding Author:
Dr. Jyotsna choubey,
Sub -DIC Bioinformatics center,
NIT Raipur (C.G.) 492010, India,
Fax: 0771-4062385,
Tel: 0771-4062385;
E-mail: [email protected], [email protected]

Received date: August 06, 2009; Accepted date: September 22, 2009; Published date: September 25, 2009

Citation: Choubey J, Patel A, Khatri S, Dewangan R, Gupta SK, et al. (2009) Homology Modell ing of Hypoxanthin-Guanine Phosphoribosyltransferase, Enzyme Involved in Salvage Pathway of Purine Metabolism. J Comput Sci Syst Biol 2:259-261. doi:10.4172/jcsb.1000039

Copyright: © 2009 Choubey J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hypoxanthin-guanine phosphoribosyltransferase (HPRT) is responsible for catalyzing a reaction which breaks down uric acid in the body. The lack of this enzyme creates a build-up of uric-acid, leading to a neurological problem, joint pain and kidney problem. The condition is called Lesch-Nyhan Syndrome. A comparative modelling of the protein Hypoxanthin-guanine phosphoribosyltransferase is performed using the modeling program modeller9v3.The following structure validation programs PROCHECK, PROSA, VERIFY3D and WHATIF are used. Descret Optimized Protein Energy (DOPE), is a statistical potential used to asses homology model in protein structure prediction. Predicted model can be useful to develop new inhibitor against Lesch-Nyhan Syndrome. CASTp can be used to study surface features and functional regions of proteins.

Keywords

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